Project Grant RF1AG079138
Award Date
9/15/22
Completion Date
8/31/25
Dollars Obligated
$4.5M
Federal Agency
National Institute on Aging
Awardee
Duke University (TP7EK8DZV6N5)
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Durham, NC 27710, USA
Similar Awards
Duke University has been awarded a $4,537,430 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, to support research under the Aging Research program (CFDA 93.866). The grant will fund a study from September 2022 to August 2025 to examine the role of cellular senescence on postoperative neuroinflammation. Specifically, the researchers will use a mouse model of orthopedic fracture to determine how senescent cell burden exacerbates systemic...
This federal Project Grant award, totaling $715,801.00, was awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program. The grant will support research at Duke University to elucidate the contributions of endothelial cells and perivascular macrophages to surgery-induced neuroinflammation, blood-brain barrier disruption, and delirium-like behavior in aging and hypertension. The research aims to ascertain the causal role of these targets as key contributors...
This $2,356,117 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to improve the perioperative management of patients with Alzheimer's disease and related dementias. The primary objectives are to: (1) identify the extent to which surgical patients with these conditions are at increased risk for adverse postoperative outcomes, and (2) estimate the association between various perioperative interventions and the incidence...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,500.00 to investigate the role of perineuronal nets (PNN) in the development of postoperative delirium in aged mice. The research aims to test the hypothesis that changes in PNN and parvalbumin-positive neurons coincide with delirium-like cognitive impairment in aged mice subjected to anesthesia, surgery, and intensive care unit (ICU)-like conditions. The project will also examine whether...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $2,415,422 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on neuroinflammation, perineural nets, and postoperative delirium. The award aims to investigate the role of the extracellular matrix and perineural nets in the pathogenesis of postoperative delirium, which is associated with increased risk of Alzheimer's disease and related...
This Project Grant award of $2,683,965.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund the development and optimization of an "all-human cellular system" for studying Alzheimer's disease (AD) and age-related dementias (ADRDs). The primary objectives are to: 1) define delivery conditions for introducing patient blood cells and plasma into a...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $805,295 to The Leland Stanford Junior University to conduct a 5-year study examining cerebrospinal fluid (CSF) and blood biomarkers that may provide insights into postoperative delirium and neurocognitive dysfunction. The key objectives are to: 1) Determine if CSF biomarkers of baseline risk, blood-brain barrier injury, inflammation, neuronal injury, and astrocyte injury/astrocytosis...
This federal Project Grant award, valued at $3,284,161 and provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports a research project investigating the role of interleukin-6 (IL-6) trans-signaling in the development of postoperative cognitive decline in aging and Alzheimer's disease populations. The University of California, San Francisco is the primary awardee. The key objectives of this 5-year research project are to: 1) determine if vulnerability to postoperative...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) for $426,829 supports the development of a microphysiological system that models the brain-meninges-lymph node axis in both healthy and Alzheimer's disease conditions. The grant, awarded to Virginia Polytechnic Institute & State University, will integrate tissue-engineered models of the human brain, lymph node, and meninges into a microfluidic device to study the interactions between these...
The National Institute on Aging awarded a $480,536 Project Grant under the Aging Research program (CFDA 93.866) to The Jackson Laboratory to fund research aimed at improving treatment for Alzheimer's disease and related dementias (ADRD). The project will assess whether manipulating the angiopoietin/tie2 (ANG/TIE2) signaling pathway can preserve blood-brain barrier (BBB) integrity and prevent cerebrovascular dysfunction, which are major contributors to many ADRDs. The research approach involves...