Project Grant R00EY033421
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $3.56 million through its Vision Research program (CFDA 93.867) to The Research Foundation for the State University of New York to conduct a prospective metabolomics study examining the relationship between nutritional intake and age-related macular degeneration (AMD) in postmenopausal women. Beginning August 1, 2025, and extending through March 31, 2029, this project will analyze approximately 2,000 metabolites from targeted...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Grant Award Summary Baylor College of Medicine received a $646,167 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. The grant funds investigations into the cellular and molecular mechanisms underlying Age-Related Macular Degeneration (AMD), the leading cause of vision loss in elderly populations. The research applies high-throughput functional genomics approaches to identify causal...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Methodist Hospital Research Institute $1,029,472 in Project Grant funding (Award Date: May 1, 2026; Completion Date: April 30, 2028) to develop innovative cell therapy for age-related macular degeneration (AMD). The research will produce scientific findings and translational research products focused on creating a sustainable mitochondrial therapy platform using...
- Federal Grant Award Summary Tufts University School of Medicine received a $504,304 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion targeted for March 31, 2031. The research project investigates the mechanistic basis of the gut-retina axis to understand how dietary patterns and gut microbiota composition influence age-related macular degeneration (AMD), a leading cause of vision loss in older adults. The...
- Federal Grant Award Summary Fannin Partners LLC received a $600,032 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025, through August 31, 2026. The award funds the development of SCG3 raptamers—modified single-stranded DNA aptamers—as a novel targeted therapy for wet age-related macular degeneration (AMD). Wet AMD, characterized by choroidal neovascularization, affects approximately 1.25 million individuals in the...
- Federal Grant Award Summary The National Eye Institute awarded a $1,488,864 Project Grant to the Icahn School of Medicine at Mount Sinai beginning September 1, 2025, through the Vision Research program (CFDA 93.867) to investigate epigenetic mechanisms controlling meibomian gland homeostasis and dysfunction in aging. The research will delineate how histone deacetylases (HDACs) and related epigenetic regulators control the maintenance and proliferation of meibomian gland basal progenitor cells,...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $896,500 under the Vision Research program (CFDA 93.867) to The Research Foundation For The State University of New York, performing at Upstate Medical Center in Syracuse, New York. The award, effective September 1, 2025, through August 31, 2027, funds research into the transcriptional dynamics of photoreceptor gene regulation, specifically investigating how the homeodomain transcription factor CRX...
The National Eye Institute (NEI) awarded a Project Grant totaling $248,737 under the Vision Research program (CFDA 93.867) with an award date of June 1, 2026, and completion date of May 31, 2029. The Research Foundation For The State University Of New York, serving as the fiscal agent, will conduct research to decipher the role of mitochondrial and autophagy dysfunction in regulating inflammatory processes during dry age-related macular degeneration (AMD) pathogenesis. This three-year project will utilize a novel mouse model and human induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) cells from both control donors and those carrying AMD risk alleles. The project aims to clarify the previously unknown interplay between organelle homeostasis/autophagy and inflammatory processes in dry AMD development, with the ultimate objective of identifying novel therapeutic strategies. As dry AMD currently lacks available treatments and represents the leading cause of blindness in elderly populations globally, the research outcomes are expected to inform the development of innovative therapeutic interventions. The research will be performed in Baltimore, Maryland, and represents the NEI's commitment to funding investigator-initiated research that advances understanding of vision diseases and expands treatment options for affected populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $248.7k | 6/5/26 |