Project Grant R21EY037020
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $448,250 to The Research Foundation for the State University of New York (Upstate Medical Center) to conduct research on the "Composition and Function of Optix-Cofactor Transcription Complexes in the Eye." The research aims to characterize the Optix protein complexes that regulate eye development and function, with the goal of understanding their specific roles in controlling gene...
- The National Eye Institute (NEI) awarded a $448,250 project grant under their Vision Research federal grant program (CFDA 93.867) to The Research Foundation for the State University of New York, operating as Upstate Medical Center. The funding supports a 2-year research project titled "YKI-MITF-ECM Regulation of Eye Progenitor Epithelium Morphology" that will explore the role of the Hippo signaling pathway, the transcription factor MITF, and extracellular matrix in the development...
- This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to investigate the role of small MAF transcription factors and their co-regulators in controlling gene expression and development of the eye lens. The $386,676 award to the University of Delaware will support research to characterize mouse models with genetic knockout of the MAFG, MAFK, and NRF2 genes, and use advanced genomic techniques to identify their direct targets...
- The University of Massachusetts Boston received a $435,052 project grant from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to conduct research on the molecular mechanisms that control the spatially precise expression patterns of photoreceptor subtypes for color vision. The long-term goal is to use the Drosophila melanogaster retina as a model to decipher the cis-regulatory mechanisms and identify conserved trans-acting factors that specify...
- This $146,922 project grant award from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at The Johns Hopkins University to understand the chromatin architectural landscape of retinal development at the single-cell level. The project aims to identify how transcription factors manipulate genomic structure to control cell fate specification in the retina, a model system for studying neuronal development. Specifically, the research will use single-cell Hi-C and...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research grant program (CFDA 93.867), provides $477,109.00 in funding to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on gene regulation underlying photoreceptor neurodegeneration in retinal degenerative diseases. The project aims to determine how the transcriptional regulator PRDM13 regulates retinal development and its association with North Carolina macular...
- The National Eye Institute (NEI) awarded a $437,310 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Rochester to conduct research on the molecular and physiological mechanisms of inner retinal remodeling in retinal degeneration. The research aims to elucidate the mechanisms behind genetic, morphological, and physiological changes in retinal ganglion cells that lead to decreased signal-to-noise ratio and corruption of retinal circuits, with the...
- This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) is funding research to develop an innovative gene therapy approach using self-amplifying and self-splicing RNA technologies. The $346,500 award, spanning September 2024 to September 2026, aims to evaluate the longevity, immunogenicity, and potential in vivo side effects of this novel mRNA-based therapy for treating inherited retinal dystrophies. The award recipient, The...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $431,750 Project Grant to the University of Louisville to study the role of neurexin proteins in retinal structure and function. The grant, effective from September 1, 2025 to August 31, 2027, aims to 1) determine the function of three neurexin genes and their isoform-specific expression patterns within the retina, and 2) characterize the cell-type-specific expression of neurexin isoforms...
This $448,250 project grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to The Research Foundation For The State University Of New York, operating as Upstate Medical Center. The grant will support an investigation into the transcriptional dynamics of the CRX homeodomain transcription factor and its role in regulating photoreceptor gene expression. The research aims to characterize CRX mobility modes, chromatin binding dynamics, and differences in CRX behavior across various photoreceptor cell types using a novel mouse model with a photoswitchable fluorescent protein knocked into the CRX gene locus. This 2-year project, running from September 1, 2025 to August 31, 2027, will provide unprecedented insights into the nuclear dynamics of CRX and its regulation of the photoreceptor transcriptome, advancing understanding of photoreceptor development and function.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $448.3k | 8/13/25 |