The University of Arizona was awarded a $625,316 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the role of RNA methylation and translational regulation in the oxidative stress response of heart failure. The research aims to elucidate how the YTHDF2 protein binds to methylated NRF2 mRNA to selectively induce its translation under oxidative stress, a process that may be impaired in end-stage heart failure. The 1-year project will utilize laboratory experiments, quantitative proteomics, and transcriptomic data from heart failure patients to advance the understanding of this novel mRNA methylation-based translational control mechanism. Findings from this work could provide insights into potential therapeutic targets for mitigating oxidative damage in heart failure.
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