Project Grant R01GM157531
- This federal Project Grant award of $125,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project at the University of California, San Diego (UCSD) to investigate how microtubule dynamics are regulated at the cellular cortex, the interface between the plasma membrane and cytoskeleton. The primary objectives of the project are to: 1) Examine the mechanisms by...
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- This Project Grant award of $254,919.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of California, San Diego (UCSD) to investigate the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Specifically, the research aims to study how post-translational modification enzymes regulate the assembly and function of DNA replication...
- The National Institute of General Medical Sciences (NIGMS) awarded a $508,315 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, San Diego (UCSD) to investigate the molecular mechanisms required for successful developmental progression from oocyte to embryo during a critical window of transcriptional silence in mammals. The overarching goal is to uncover post-transcriptional regulatory mechanisms, such as mRNA poly(A) tail dynamics, that...
- This federal Project Grant award, valued at $372,880 and issued on May 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project aimed at understanding how cells regulate protein synthesis to maintain homeostasis during cellular stress. The key focus is on investigating the role of the translation initiation factor eIF2 and its phosphorylation in modulating gene...
- The National Science Foundation awarded a $138,000 Project Grant to support research from June 2021 to May 2023 titled "Uncovering the Molecular Mechanisms of Mitochondrial Proteostasis." The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing knowledge and enhancing understanding of major problems. Funds will support the grantee's research...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This $414,159 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the differential stress responses of organelles in eukaryotic cells. The research aims to investigate the molecular mechanisms underlying how cells employ different strategies to respond to nutritional deprivation versus endoplasmic reticulum (ER) stress. The principal investigator at the...
- This federal Project Grant award of $686,324, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports mechanistic studies on the role of the E3 ubiquitin ligase MARCH5 in regulating mitochondrial and peroxisomal function. The grant recipient, the University of Maryland, Baltimore, will investigate how MARCH5 activity is vital for peroxisome biogenesis and how it protects mitochondria from the toxic...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $1,345,188.00 to the University of California, San Diego (UCSD) to elucidate the mechanisms by which the eukaryotic initiation factor 5A (EIF5A) influences mitochondrial function. The key objectives of this research are to investigate how EIF5A depletion leads to ribosome stalling on mitochondrial proteins during co-translational import, triggering a mitochondrial import stress response and impacting overall cellular health and function. The research will leverage gene expression reporters, fluorescent microscopy, proteomics, CRISPR library screening, and cryo-electron tomography to provide comprehensive insights into EIF5A's role in mitochondrial biology. The findings are expected to advance the understanding of fundamental mitochondrial processes and highlight potential therapeutic approaches for diseases associated with mitochondrial dysfunction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/2/25 |