This $473,096 Project Grant awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program supports research to understand the mechanisms and impact of direct mitochondrial lactate oxidation in heart failure. The primary awardee, the University of Utah's Office of Sponsored Projects Division, will conduct in vivo and in vitro studies to quantify direct versus indirect mitochondrial lactate oxidation in healthy and failing hearts, determine if mitochondrial lactate transporter MCT1 is necessary for enhanced lactate metabolism in cardiac injury, and identify the lactate dehydrogenase isoform responsible for mitochondrial lactate dehydrogenase activity. This research aims to reveal a paradigm shift in how lactate is metabolized in the healthy and failing heart, thereby guiding the development of future therapies to improve cardiac bioenergetics and function in heart failure patients.
Generated 3/4/25, 5:22 AM