Project Grant K99NS142567
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This federal Project Grant award of $238,410 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders will fund a 5-year mentored research project led by Dr. Sarah Kaufman at the University of California, San Francisco. The project aims to elucidate the mechanisms underlying tau aggregation and neurotoxicity in Alzheimer's disease and frontotemporal lobar degeneration. The research...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,540,579 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regenerative Research Foundation in Rensselaer, NY. The 2-year grant, with a start date of June 1, 2025, will fund the development and validation of a novel, cellularly complex 3D human cell model of frontotemporal dementia (FTD) due to MAPT gene mutations. The goal is to create a model...
- This $3,081,936 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of California, San Diego (UCSD) to investigate the mechanisms underlying TDP-43 proteinopathies, which are associated with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,275,512 to The Regents of the University of California, San Francisco (UCSF) to conduct research on understanding how changes in progranulin (PGRN) protein species impact the accumulation of the TDP-43 protein, which is associated with neurodegenerative disorders like Alzheimer's disease and frontotemporal dementia. The research aims to elucidate the role of lysosomes and lysosomal...
- This federal Project Grant award for $419,375.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the University of Florida to support the research project "Pathological Implications of the Tau-RNA Interaction". The project aims to investigate the role of the interaction between the tau protein and cellular RNA in the accumulation and toxicity of tau, which is associated with neurodegenerative disorders such as...
- This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
- This $1,592,854 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Illinois to investigate the role of tau protein misfolding and hyperphosphorylation in Alzheimer's disease and related dementias. The central hypothesis is that pathogenic forms of tau represent a disruption of tau's normal scaffolding and signaling functions, leading to dysregulation of key kinases like CK2 and JNK. The research aims to define how...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $165,348.00 to the Rector & Visitors of the University of Virginia to investigate the cellular and molecular mechanisms by which hyperphosphorylated tau protein induces neurotoxicity and cognitive deficits. The research aims to characterize the effects of hyperphosphorylated tau oligomers on brain function using transcriptomic profiling and neurophysiology approaches. Specifically, the...
This Project Grant award of $119,367, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to characterize the role of the protein tau and its interactions with RNA processing in frontotemporal dementia (FTD). The principal investigator at the University of California, San Francisco (UCSF) aims to (1) investigate how tau, an RNA-binding protein, facilitates mRNA stability and transport, and (2) identify the mechanisms by which disruptions in tau function lead to aberrant RNA processing and localization in FTD. This research could provide critical insights into the molecular drivers of tauopathies, a group of neurodegenerative diseases including Alzheimer's disease and FTD. The award has a performance period from August 11, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $119.4k | 8/11/25 |