Project Grant R21AG085079
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This $1,592,854 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Illinois to investigate the role of tau protein misfolding and hyperphosphorylation in Alzheimer's disease and related dementias. The central hypothesis is that pathogenic forms of tau represent a disruption of tau's normal scaffolding and signaling functions, leading to dysregulation of key kinases like CK2 and JNK. The research aims to define how...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This federal Project Grant award of $437,250.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development of new imaging tools to study the various forms of the tau protein, which is implicated in Alzheimer's disease. The goal is to create a peptide-based probe that can detect tau in its soluble, liquid-liquid phase separation, and liquid-solid phase separation states within living cells using an aggregation-induced emission (AIE) approach. This...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $165,348.00 to the Rector & Visitors of the University of Virginia to investigate the cellular and molecular mechanisms by which hyperphosphorylated tau protein induces neurotoxicity and cognitive deficits. The research aims to characterize the effects of hyperphosphorylated tau oligomers on brain function using transcriptomic profiling and neurophysiology approaches. Specifically, the...
- This Project Grant award of $130,302 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports research to investigate the molecular and functional impacts of pathological tau accumulation in basal forebrain cholinergic neurons (BFCNs) and its implications for Alzheimer's disease. The research aims to reveal the interplay between tau pathology and cholinergic dysfunction, leveraging human induced pluripotent stem cell-derived BFCNs and a...
- This $1,526,066 Project Grant was awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The Leland Stanford Junior University (Stanford University). The award, with a start date of June 1, 2025 and an ultimate completion date of April 30, 2030, will fund research to investigate the shared mechanisms of tau protein toxicity across multiple neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. The...
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various neurological disorders including Alzheimer's disease, epilepsy, and autism. The project will utilize cell type-specific tau ablation and chemically induced imbalance, combined with transcriptomic and proteomic analyses of excitatory forebrain neurons, to identify the critical mechanisms by which tau enables and its reduction counteracts the development of this neuronal dysfunction. The findings could provide insights into tau biology, help guide tau-targeting therapies, and reveal additional indications and drug targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/19/23 | ||
| Not listed | $519.8k | 9/15/23 |