Project Grant R21AG093972

Award Date 6/1/25
Completion Date 5/31/26
Dollars Obligated $419K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Gainesville, FL 32611, USA
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This $1,592,854 project grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Illinois to investigate the molecular mechanisms underlying tau protein dysfunction in neurodegenerative tauopathies, including Alzheimer's disease and related dementias. The overarching goal is to understand how disease-related changes in tau conformation and post-translational modifications disrupt tau's normal scaffolding functions and lead to dysregulation of key...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $320,000 will fund a study on alternative polyadenylation (APA) regulation in Alzheimer's disease (AD). The research, conducted by the University of Texas Medical Branch at Galveston, aims to comprehensively profile APA transcripts and gene expression in neurons expressing wild-type and mutant tau proteins. Specifically, the study will leverage the Poly(A)-ClickSeq (PAC-Seq)...
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