Project Grant K08NS140640
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
- This $3,109,857 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development and validation of a human induced pluripotent stem cell (iPSC)-derived hippocampal assembloid model to study the interaction between interneurons, tau toxicity, and circuit-related neuronal dysfunction associated with genetic forms of dementia. The research...
- This Project Grant award of $119,367, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to characterize the role of the protein tau and its interactions with RNA processing in frontotemporal dementia (FTD). The principal investigator at the University of California, San Francisco (UCSF) aims to (1) investigate how tau, an RNA-binding protein,...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This Project Grant award of $130,302 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports research to investigate the molecular and functional impacts of pathological tau accumulation in basal forebrain cholinergic neurons (BFCNs) and its implications for Alzheimer's disease. The research aims to reveal the interplay between tau pathology and cholinergic dysfunction, leveraging human induced pluripotent stem cell-derived BFCNs and a...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- The National Institute on Aging (NIA) awarded a $4,276,054 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) on September 1, 2024. The project aims to develop mathematical models to quantitatively test and validate hypotheses regarding the selective vulnerability of genes, cells, and neural networks in mouse models of Alzheimer's disease (AD) tauopathy. The research will leverage two enabling...
This federal Project Grant award of $238,410 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders will fund a 5-year mentored research project led by Dr. Sarah Kaufman at the University of California, San Francisco. The project aims to elucidate the mechanisms underlying tau aggregation and neurotoxicity in Alzheimer's disease and frontotemporal lobar degeneration. The research plan includes technical training in iPSC-derived neuron cultures, CRISPR functional genomics, bioinformatics, and neuropathologic analysis, as well as developing skills in scientific communication, grant writing, mentorship, and lab management. This comprehensive research and career development initiative seeks to establish Dr. Kaufman as an independent leader in neurodegenerative disease research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $238.4k | 7/31/25 |