Project Grant K99GM166955
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $406,026 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop biophysical models of biomolecular condensate dynamics. The work addresses the need for quantitative mathematical models to interpret experimental measurements of biomolecular condensates—non-membrane-bound organelles formed through phase separation that enable cellular functions including ribosomal...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $420,936 for a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on April 1, 2026. The award funds research investigating mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis. The research addresses how cargo controls the nucleation and growth of...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $414,709 in project grant funding on May 1, 2026, under Biomedical Research and Research Training (CFDA 93.859) to develop and apply crosslinking mass spectrometry methods for mapping the molecular architecture of biomolecular condensates. The work spans three broad thrusts: advancing XL-MS tools and methodology to capture protein-RNA interactions through photo-crosslinking and developing computational...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $426,250 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to probe translation regulation by imaging single protein-mRNA interactions in live cells. The research project establishes systems to visualize single protein-RNA interactions in live cells and refines single-molecule translation assays to correlate protein binding with translation dynamics. The work...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $833,955 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop tools for mapping the glycan-protein interactome using bioorthogonal chemistry and deep learning. The recipient will synthesize and optimize bifunctional ganglioside probes bearing photoaffinity diazirines and click alkyne tags, deliver these probes to human cancer cell lines to capture...
- The National Institute of General Medical Sciences awarded $1.688 million to Pacific Northwest National Laboratory, a division of Battelle Memorial Institute, on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multimodal measurement platform for unambiguous lipid identification. The recipient will build a high-resolution ion mobility-mass spectrometry (IM-MS) system designed to distinguish free fatty acids and lipid isomers in complex...
- The National Institute of General Medical Sciences awarded Purdue University $303,804 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a correlative and multimodal molecular imaging platform for spatially-resolved analysis of biomolecules in biological tissues. The project focuses on advancing nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI), an ambient ionization technique that enables highly...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $458,950 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research deciphering signaling network dynamics, structure, and function. The research investigates how cells detect and respond to environmental cues and intercellular signals through complex, dynamic signaling networks. The work pursues two complementary directions: developing high-throughput...
- The National Institute of General Medical Sciences awarded Imagen Bioworks Inc. $349,243 on September 12, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop SPOTLIGHT-OMICS, a scalable spatiotemporal-omics platform for pre-clinical drug discovery. The platform isolates disease-relevant cell subpopulations showing altered spatiotemporal phenotypes after drug exposure and subjects isolated cells to subsequent omics assays, linking cellular spatiotemporal...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded The Johns Hopkins University $116,625 on July 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to interrogate glutamate carboxypeptidase II (GCPII)-mediated glutamate signaling in the gastrointestinal tract and its role in intestinal homeostasis. The research addresses an unmet clinical need for mechanistically novel therapeutics to treat inflammatory bowel disease, as up...
The National Institute of General Medical Sciences awarded The Johns Hopkins University $133,515 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multi-omic mass spectrometry imaging platform for visualizing inflammatory disease biomarkers in tissue sections. The funded work addresses technical limitations in current matrix-assisted laser desorption/ionization mass spectrometry imaging approaches by developing optimized protocols and integrated computational frameworks. The recipient will create an enhanced multi-omic mass spectrometry imaging platform that combines on-tissue chemical derivatization with on-tissue tryptic digestion and laser ablation inductively coupled plasma mass spectrometry to enable simultaneous detection of prostaglandins, proteins, and metals from a single tissue section. Computational frameworks under development will include molecular probabilistic mapping for improved quantification, analysis, and visualization of multi-omic datasets. The resulting tissue maps will show spatial distributions of prostaglandins, tryptic peptides, and metallomic signatures, addressing current gaps in understanding how molecular classes of prostaglandins, proteins, and metals interact in inflammatory processes. Performance occurs in Baltimore, Maryland, with a period from September 1, 2026, through August 31, 2028. This is a Project Grant, a standard assistance mechanism under NIGMS's portfolio of investigator-initiated biomedical research funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.5k | 8/21/26 |