Project Grant R35GM161776
- Federal Project Grant Award Summary The Johns Hopkins University received a $525,416 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. This research project focuses on elucidating fundamental cellular processes related to gene expression regulation through transcription and DNA damage repair mechanisms, specifically investigating the...
- Federal Grant Award Summary The Johns Hopkins University received a $856,135 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences (CFDA 47.074 - Biological Sciences program) effective September 1, 2025 through August 31, 2029. This research initiative will develop and apply advanced single-molecule tracking (SMT) methods to measure protein production regulation in individual live cells, addressing a critical gap in cellular biology research. The...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $2.14 million Project Grant effective September 1, 2025 through August 31, 2029 under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental research into the molecular mechanisms of ribosome-mediated kinase signaling, specifically investigating how ribosomes directly sense cellular stress conditions and activate stress...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $450,313 Project Grant effective June 1, 2025 through May 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research investigating the molecular mechanisms and protein dynamics underlying nonribosomal peptide synthetases (NRPSs)—multidomain enzymatic complexes capable of synthesizing complex...
- Federal Project Grant Award Summary The Johns Hopkins University received a $454,478 Project Grant award effective September 10, 2025, through August 31, 2030, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). This focused technology research and development initiative aims to advance tools for defining the glycan-protein interactome by merging bioorthogonal chemistry and deep learning computational approaches....
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $286,729 Project Grant to the University of California, Los Angeles, effective March 1, 2026, through January 31, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports research investigating the molecular dynamics of eukaryotic translation and messenger ribonucleic acid (mRNA) decay. The research aims to elucidate how cells distinguish between normal and...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $426,479 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025 through August 31, 2030. This award supports the development of statistical and computational frameworks for precision risk stratification, diagnosis, and treatment through synthesis of genomic and clinical data from biobanks, electronic health...
- This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research investigating the molecular mechanisms that control translation initiation in human cells. The five-year award, valued at $484,000 and running from September 1, 2025 through August 31, 2030, is being conducted by Fred Hutchinson Cancer Center in Seattle, Washington. The research will employ single-molecule...
- Federal Grant Award Summary The Johns Hopkins University received a $426,360 Project Grant award dated July 29, 2025, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This grant supports the Biomedical Engineering (BME) Training Program, an institutional research training initiative designed to prepare doctoral students for careers in biomedical research and engineering. The program delivers comprehensive...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded The Johns Hopkins University a Project Grant totaling $999,993 on August 1, 2025, to support fundamental research on the assembly and regulation mechanisms of filamentous signaling platforms through July 31, 2029. This research aims to elucidate how cells regulate molecular interactions through the sequential assembly of supramolecular protein structures that trigger...
The National Institute of General Medical Sciences awarded The Johns Hopkins University a $426,250 Project Grant (CFDA 93.859: Biomedical Research and Research Training) effective March 1, 2026 through February 28, 2031 to investigate translation regulation through single-molecule imaging of protein-mRNA interactions in live cells. The research will establish visualization systems for single protein-RNA interactions, develop refined single-molecule translation assays, and create tools to correlate protein binding dynamics with translation outcomes. Additionally, the project will investigate ribosome-associated quality control factors such as ZNF598 and ASCC3 in resolving ribosomal collisions, and examine the role of mRNA looping and initiation factor binding in activating translation. The research directly addresses gaps in understanding "bursting translation"—the dynamic transitions of mRNAs between translationally active and inactive states—which has implications for diseases including cancer and neurodegenerative disorders. Building upon the investigator's Single-molecule Imaging of NAscent Peptides (SINAPS) technology, this fundamental research will generate novel methodologies and insights into in vivo mRNA translation dynamics and regulation, with potential applications for developing therapeutic strategies targeting translation-related disorders. The work will be conducted at the Johns Hopkins University campus in Baltimore, Maryland.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.3k | 2/18/26 |