Project Grant R01GM157351
- Federal Project Grant Award Summary Purdue University received a $150,104 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 12, 2026, with a completion date of November 16, 2028. The grant supports fundamental research aimed at determining the role of CsoS2 protein in carboxysome assembly and regulation—a critical component of the carbon dioxide concentrating mechanism found in...
- Federal Grant Award Summary Purdue University received a $395,455 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2030. The award funds development of computational methods and deep learning-based approaches for biomolecular structural modeling of cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) data. The research addresses...
- Federal Grant Award Summary Purdue University received a $412,632 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award supports research and development of biocatalytic synthesis methods for complex medicinal small molecules informed by artificial intelligence-driven planning. The project addresses critical gaps in computer-aided synthesis...
- Federal Grant Award Summary Purdue University received a $375,337 Project Grant from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded July 1, 2025, with a completion date of June 30, 2027. The grant funds development of fluorescence-detected photothermal infrared (F-PTIR) microscopy technology designed to track intracellular processes governing messenger...
- Federal Grant Award Summary Purdue University received a $268,725 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025, through June 30, 2030. The award funds the Purdue Drug Discovery Training Program (PDD-TP), a predoctoral training initiative designed to provide cross-disciplinary education at the chemical-biology interface. The program delivers comprehensive graduate...
- Federal Grant Award Summary Purdue University received a $146,922 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective June 1, 2025, through May 31, 2028. The award funds research in electrochemical fluorination for organic synthesis, focusing on the development of innovative synthetic methods to selectively install fluorinated functional groups—specifically sulfonyl fluorides (SO2F) and aryl...
- Federal Project Grant Award Summary Nanoengineering Corporation received a $338,843 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) awarded on June 15, 2025, with completion targeted for May 31, 2026. The grant supports the development of an electrospray differential mobility analysis (ES-DMA) soft-landing system designed to improve structural analysis of protein complexes using cryo-electron...
- Federal Project Grant Award Summary Indiana University received a $446,435 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective September 4, 2025, with completion targeted for June 30, 2029. The grant supports fundamental research into the mechanisms of pterin-dependent regulation in proteobacterial systems, specifically investigating how bacteria transition from free-living to biofilm...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $382,026 to Indiana University (Trustees of Indiana University) on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research initiative titled "Target-Specific Dyes with Responsive Long-Lived Fluorescence Lifetimes for Biological Interrogation," with performance through August 31, 2030. The project...
- Summary of Federal Project Grant Award The National Institute of General Medical Sciences (NIGMS) awarded $423,330 to the University of Kansas Center for Research Inc. on August 1, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop innovative technologies in biomedical mass spectrometry. Over the five-year project period (through June 30, 2030), the award will fund the development of a noninvasive, pain-free sampling method for lipidomics studies using...
Federal Project Grant Award Summary Purdue University received a $303,804 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026 through February 28, 2029. The award funds the development of a highly sensitive correlative and multimodal molecular imaging platform utilizing nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI) technology. This research initiative will advance spatially-resolved analysis of multiple classes of biomolecules in biological tissues, achieving subcellular spatial resolution approaching traditional histology imaging with sub-femtomole sensitivity while avoiding specialized sample pretreatment requirements. The project deliverables include novel strategies for enhancing extraction and ionization efficiency of low-abundance and poorly ionizable analytes, as well as robust experimental and computational approaches for correlative and multimodal tissue imaging. Proof-of-concept validation will be demonstrated through examination of inflammatory response mechanisms using a streptozotocin-induced mouse model. The research outcomes will provide cell-specific, spatially-resolved molecular maps of biological systems with unprecedented chemical specificity, supporting broader applications in understanding tissue structure and function across health and disease states.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $303.8k | 3/12/26 |