Project Grant R01GM160587
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- This $306,782 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the continued development and validation of a panel of six sialoglycan-recognizing probes (SGRPs) by Z Biotech, LLC. The project aims to optimize these specialized molecular tools, which leverage naturally evolved microbial sialoglycan-binding proteins, for use in common laboratory techniques like ELISA, Western...
- This federal Project Grant award of $390,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a versatile, small molecule-based platform to map the "reader proteins" of critical glycosylation, such as sialylation and core fucosylation. The research program seeks to decipher the protein-carbohydrate interaction code, particularly for disease-related interactions, to lay the...
- The University of Southern California received a $342,342 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for their project titled "CHEMISTRY-ENABLED GLYCOSCIENCE." The project aims to develop and apply chemistry-enabled approaches to address unresolved questions in the field of glycoscience, which studies the role of glycans (complex carbohydrates) in biological processes and...
- This $327,085 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of new tools and strategies to advance the understanding of lectin proteins and their roles in human health. The key objectives of this 1-year project include: 1) Creating tools to assess how soluble human lectins interact with and influence microbial communities, 2) Developing a...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...
- The National Institute of General Medical Sciences (NIGMS) awarded a $382,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Texas A&M Engineering Experiment Station (Tees) for the project "Role of Membrane Dynamics in Cell Surface Glycan Recognition" from January 1, 2025 to December 31, 2029. The goal of this project is to investigate how the spatial organization of glycan ligands on cell membranes influences glycobiology processes, and to develop...
- The National Institute of General Medical Sciences (NIGMS) awarded a $434,385 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maine System, University of Maine Division. The grant, awarded on September 15, 2024, supports the development of a customizable 3D matrix to investigate the role of glycans in human health and disease. The research aims to enable the identification and characterization of glycan-protein interactions in a...
- The federal Project Grant award of $186,354 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is being used to conduct research on the roles of protein glycosylation in prokaryotes. The project aims to perform quantitative glycoproteomic analyses of the opportunistic bacterial pathogen Pseudomonas aeruginosa during different stages of biofilm formation and in response to antibiotics. Additionally, the...
- The National Institute of General Medical Sciences (NIGMS) has awarded a 5-year, $471,019 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Georgia Tech Research Corporation (Georgia Tech Research Corp) to characterize extracellular glycoproteins and study their functions. The project aims to develop innovative mass spectrometry-based methods to comprehensively analyze glycoproteins on cell surfaces and in the secretome, as well as investigate the...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $454,478 to The Johns Hopkins University for a project titled "Perfecting Tools to Define the Glycan-Protein Interactome". The project aims to develop advanced chemical probes and computational techniques to map the interactions between glycans (sugar structures) and proteins, which play critical roles in regulating cell physiology and are implicated in various diseases. The research leverages the unique properties of gangliosides, a class of glycolipids, to create bifunctional probes that can capture glycan-protein complexes for proteomic analysis. The 5-year project period runs from September 10, 2025 to August 31, 2030 and builds upon the university's previous work in this area, with the goal of advancing the fundamental understanding of the "glycan code" and its potential impact on human health across cancer, immune disorders, and neurological diseases.