Project Grant R03OD040606
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $454,478 Project Grant (CFDA 93.859: Biomedical Research and Research Training) on September 10, 2025, to support research through August 31, 2030. The grant funds technology development to advance understanding of the glycan-protein interactome—the complex interactions between sugar structures (glycans) on cell surfaces and their protein binding partners. The research...
- Federal Grant Award Summary The Johns Hopkins University received a $777,498 Project Grant award from the National Institutes of Health (NIH) Office of the Director through the Trans-NIH Research Support program (CFDA 93.310), effective February 17, 2026, through January 31, 2031. The award funds research titled "Modification of the Predisposition for Ectopic Calcification," which investigates the underlying mechanisms of pathological calcification in cardiac valves and arterial...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $426,479 Project Grant effective September 1, 2025 through August 31, 2030 under the Biomedical Research and Research Training program (CFDA 93.859). The award funds development of statistical and computational methods to synthesize genomic and clinical data from biobanks, electronic health records, and clinical registries for precision risk stratification and...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a $232,938 Project Grant on February 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to generate critical knowledge on neuronal membrane proteasome (NMP) peptide signaling in the peripheral nervous system. The research focuses on identifying and characterizing NMP-derived peptides expressed in...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant totaling $559,800 under the Biomedical Research and Research Training program (CFDA 93.859) for the period July 1, 2026 through March 31, 2031. This award supports the investigation and development of rapafucins—a 45,000-compound library of rapamycin-like macrocyclic natural products designed to address the challenge of targeting...
- Federal Grant Award Summary The National Institutes of Health (NIH) Office of the Director, through the Trans-NIH Research Support program (CFDA 93.310), awarded a $280,729 Project Grant to The Washington University in University City, Missouri, on August 6, 2025, with a completion date of July 31, 2030. This award supports the development and validation of novel label-free nonlinear optical microscopy technology designed to observe the spatial and temporal dynamics of host-microbe...
- Federal Project Grant Award Summary The Johns Hopkins University received a $2.33 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 1, 2025, with completion scheduled for August 31, 2029. The award supports research investigating the pathogenesis of necrotizing enterocolitis (NEC), the leading cause of gastrointestinal disease...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Johns Hopkins University a Project Grant of $725,520 beginning September 15, 2025, and concluding June 30, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research focuses on understanding aberrant N-glycosylation in Crohn's disease as a precision medicine opportunity. The project investigates the role of manganese...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $414,709 Project Grant effective May 1, 2026, through February 28, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research to map the molecular architecture of biomolecular condensates using crosslinking mass spectrometry (XL-MS), a technique that captures structural information about proteins in their native...
- Federal Grant Award Summary The Johns Hopkins University received a $412,124 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on March 18, 2026, with a completion date of January 31, 2031. The award supports research investigating the mechanobiological regulations of collective cell movement, with the goal of decoding fundamental mechanical principles governing tissue morphogenesis...
The Johns Hopkins University received a $116,625 Project Grant award effective July 1, 2026 through March 31, 2028 from the National Institutes of Health Office of the Director under the Research Infrastructure Programs (CFDA 93.351). The award supports research to interrogate glutamate carboxypeptidase II (GCPII)-mediated glutamate signaling in the gastrointestinal tract and its role in intestinal homeostasis. This research addresses an unmet clinical need for mechanistically novel therapeutics to treat inflammatory bowel disease (IBD), which affects approximately 30% of patients inadequately managed by existing drugs. The project delivers two primary research deliverables: (1) application of matrix-assisted laser desorption/ionization (MALDI) imaging to visualize glutamate and related metabolite distributions in ileal tissue samples from a novel humanized mouse model (HUGCPII KI) designed to recapitulate epithelial GCPII upregulation observed in human IBD patients, with evaluation of small molecule GCPII inhibitor effects on glutamate metabolism; and (2) development and characterization of a novel approach method comprising patient-derived ileal enteroid-immune co-cultures to study the consequences of GCPII dysregulation. These research activities are designed to elucidate the precise pathobiological mechanisms of GCPII in IBD and support advancement of GCPII inhibitors as therapeutic candidates.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $116.6k | 7/6/26 |