Project Grant R41GM156536
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- The National Institute of General Medical Sciences (NIGMS) awarded Fluorofinder, LLC a $356,190 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to advance a novel microscopy workflow tool. The tool is designed to streamline assay development, improve awareness and education around optimal selection of microscopy assay components (instruments and reagents), and enhance reproducibility in the field. The project aims to address common challenges in...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $306,700 Project Grant to Rybodyn, Inc. for the development of a novel spatial biology platform for cost-effective and scalable protein profiling. The goal of this 12-month project is to create a non-destructive, image-free spatial biology platform that can achieve sub-cellular resolution of protein presence and abundance using proprietary barcoded tags...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The award supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This innovative instrument is designed to enable non-destructive profiling and mapping of...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,816 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Narwhal Bio, Inc. in San Diego, CA. The grant supports the development of a prototype instrument, software, and consumable for non-invasive live-cell identification, tagging, and downstream characterization. This novel platform aims to enable researchers to study clinically relevant cell-cell interactions that drive diseases like...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $675,609.00 to Ometa Labs LLC to develop a bioinformatics platform for large-scale untargeted metabolomics analysis. The award period runs from August 1, 2025 to July 31, 2027 and will support the creation of innovative computational tools and techniques to facilitate comprehensive analysis of metabolic profiles. This...
- This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of an integrated workflow that combines computation and experimentation to efficiently expand a metabolomics-enabled drug discovery (MetD4) dataset. The primary focus is on developing neural network models to enable efficient metabolomic characterization of compound libraries, which will aid in...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $423,616 Project Grant to Brown University. The grant, effective from September 1, 2025 to June 30, 2030, will support the development of integrative computational models to decode disease mechanisms and predict drug synergies in spatial transcriptomics. The research aims to uncover how the spatial arrangement of cells within tissues (cellular spatial...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current profiling techniques that fail to assess how drugs affect the spatiotemporal properties of cells, which is important for understanding disease abnormalities and drug mechanisms. The project seeks to create a scalable spatiotemporal-omics platform to improve the accuracy of predicting the clinical efficacy of drug candidates during pre-clinical drug discovery, ultimately revolutionizing the biopharmaceutical industry.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $349.2k | 9/12/25 |