Project Grant K99DE034068
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $688,679 to the University of Southern California (USC) to develop innovative technology for comprehensively mapping the transcriptomes and lineage histories of all cell types in the vertebrate face. The project aims to define the diversity of mesenchymal progenitors, lineage relationships, and variations across...
- This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
- This $162,281 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will support research to investigate the gene regulatory networks underlying meningeal development and the origin of meningiomas. The awardee, the California Institute of Technology (Caltech), will explore the conserved neural crest and mesoderm origins of the meninges in zebrafish models and develop an...
- This federal Project Grant award of $1,608,956.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to generate a single-cell multimodal atlas of human craniofacial development and conduct evolution-driven computational and experimental studies of enhancers involved in human midface development. This research is intended to improve understanding of the genetic...
- The federal Project Grant award titled "NEURAL CREST REGULATION OF EMBRYONIC CALCIUM UPTAKE" was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $200,625 award supports research at the Children's Hospital Medical Center in Cincinnati, Ohio to determine the role of neural crest cells in regulating calcium uptake and bone mineralization during vertebrate...
- This federal Project Grant award of $315,289.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The award supports research to investigate the role of the SIX1 transcription factor in neural crest cell fate determination within the mouse mandibular arch. The project aims to identify changes in cell populations and the impact of SIX1 variants linked to Branchio-Oto-Renal syndrome on...
- This Project Grant award of $889,616.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the cellular and molecular mechanisms by which specific RNAs and proteins enriched in neural crest cell (NCC) protrusions promote NCC migration. The research aims to determine the transcriptome and proteome of NCC projections and test their function, as well as examine the localization...
- This Project Grant award, totaling $493,458, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The grant aims to investigate the role of ARID1 proteins in regulating cranial neural crest cell (CNCC) development, which is critical for proper craniofacial formation. The project will examine how ARID1A and ARID1B, subunits of the chromatin remodeling complex BAF, dynamically...
- This Project Grant award, with a total funding of $222,211, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The award supports research to understand how the chromatin modifiers PRDM3 and PRDM16 epigenetically control gene expression during craniofacial development. The project aims to define the molecular mechanisms regulating Wnt/β-catenin signaling in chondrocytes, identify...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to establish a novel zebrafish model of syndromic craniosynostosis. The $313,000 award to Emory University will enable comprehensive phenotypic, mechanistic, and genetic analyses of the craniosynostosis mutant zebrafish to better understand the underlying pathological mechanisms. The research aims to identify...
The federal Project Grant award titled "FROM CREST TO BONE: UNDERSTANDING NEURAL CREST SKELETOGENIC CAPACITY ALONG THE NEURAL AXIS" is funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The $162,281 grant, awarded on August 6, 2025, supports research at the California Institute of Technology (Caltech) to investigate the fundamental gene regulatory networks driving neural crest-derived bone formation in sturgeons, a primitive group of bony fish. The goal is to uncover how the ancient neural crest's ability to contribute to skeletal tissue formation along the entire body axis may have evolved into the mammalian craniofacial bone formation capacity. The research leverages innovative techniques like hybridization chain reaction and CRISPR/Cas9 mutagenesis to explore this scientific question.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $162.3k | 8/6/25 |