This federal Project Grant award of $503,648 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the genetic mechanisms driving the specification of oral/dental and skin lineages in the mandibular ectoderm. The research aims to determine how transcription factor interactions regulate these epithelial patterning processes, including identifying the chromatin-level regulation...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
This Project Grant award of $3,069,994.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports a research program focused on investigating skeletal stem cell plasticity as a central mechanism underlying craniofacial bone diseases. The research aims to elucidate the roles of periosteal, endosteal, and chondrocyte stem cells in intramembranous and endochondral craniofacial bone...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $493,458 to Childrens Hospital Medical Center in Cincinnati, Ohio to conduct research on the role of ARID1 proteins in craniofacial neural crest cell development. The project aims to investigate how ARID1A and ARID1B subunits of the BAF chromatin remodeling complex regulate multipotency,...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,325,889 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Southern California on September 19, 2024. This grant, titled "Regulating Skeletal Connectivity in Craniofacial Development and Disease," will support a comprehensive and forward-thinking research program led by Dr. Amy Merrill that investigates the craniofacial skeleton as a multi-tissue...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, provides $688,679 to the University of Southern California (USC) to conduct innovative research mapping the transcriptomes and lineage relationships of cell types in the developing vertebrate face. The goal is to develop new technology capable of uniquely labeling and permanently tracing the lineages of all cells...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This federal Project Grant award of $646,212, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of primary cilia and the C2CD3 protein in craniofacial skeletal development. The research aims to determine if skeletal differentiation is impaired in human induced pluripotent stem cell-derived neural crest cells carrying OFD14-causing C2CD3 variants, examine how C2CD3...
This Project Grant award of $313,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The funding supports a secondary analysis of whole genome sequencing data from the Gabriella Miller Kid's First orofacial cleft cohorts to identify genetic variants located within regulatory elements active in the facial ectoderm and deep intronic variants in ectodermally expressed genes that...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $178,848 five-year Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Regents of the University of California, San Francisco (UCSF) to study the role of the p120-catenin protein in craniofacial development and disease. The project aims to elucidate the molecular mechanisms underlying cleft lip formation, leveraging newly developed mouse models and live imaging approaches to understand how...