This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,867,823 to support research on the genomic and developmental mechanisms underlying a congenital craniofacial disorder called frontonasal dysplasia (FND). The research aims to study how structural variations in the genome can disrupt the regulation of neighboring genes, such as SIX2 and SIX3, and lead to craniofacial...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, provides $688,679 to the University of Southern California (USC) to conduct innovative research mapping the transcriptomes and lineage relationships of cell types in the developing vertebrate face. The goal is to develop new technology capable of uniquely labeling and permanently tracing the lineages of all cells...
This federal Project Grant award of $821,236.30 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research on the role of SOXE transcription factors in neural crest cell specialization. The University of Kentucky Research Foundation is the prime awardee and will utilize omics-based approaches, gain and loss of function experiments, and SOX9-SOX10 chimera constructs to assess how and when...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,608,956 to The Regents of the University of California, operating as Lawrence Berkeley National Laboratory, to conduct research on human midface development and genetic factors underlying craniofacial birth defects. The key activities include: Generating a single-cell multimodal atlas of human craniofacial...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This federal Project Grant award of $503,648 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the genetic mechanisms driving the specification of oral/dental and skin lineages in the mandibular ectoderm. The research aims to determine how transcription factor interactions regulate these epithelial patterning processes, including identifying the chromatin-level regulation...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,325,889 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Southern California on September 19, 2024. This grant, titled "Regulating Skeletal Connectivity in Craniofacial Development and Disease," will support a comprehensive and forward-thinking research program led by Dr. Amy Merrill that investigates the craniofacial skeleton as a multi-tissue...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to establish a novel zebrafish model of syndromic craniosynostosis. The $313,000 award to Emory University will enable comprehensive phenotypic, mechanistic, and genetic analyses of the craniosynostosis mutant zebrafish to better understand the underlying pathological mechanisms. The research aims to identify...
This $521,209.45 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, supports research to delineate the role of the transcriptional repressor ZEB2 in human neural crest cell formation, craniofacial differentiation, and Mowat-Wilson syndrome. The 3-year award to The Research Foundation for the State University of New York (RF SUNY) will fund investigations into the...
This Project Grant award of $3,069,994.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports a research program focused on investigating skeletal stem cell plasticity as a central mechanism underlying craniofacial bone diseases. The research aims to elucidate the roles of periosteal, endosteal, and chondrocyte stem cells in intramembranous and endochondral craniofacial bone...