This federal Project Grant award for $149,284, provided by the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs), supports research to understand how chronic cocaine use disrupts the brain's dopamine system and alters the neural processing of aversive, non-drug stimuli. The primary objectives are to: 1) Define the temporal parameters under which dopamine release modulates the activity of specific neuron populations in the nucleus accumbens at baseline...
This federal Project Grant award of $148,568, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to dissect the mechanisms of dopamine transmission and its role in reward-related behaviors. The award aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, which is critical for motivation, reward learning, and decision-making. The project will explore how...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), aims to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the comorbidity of HIV and cocaine use disorders (CUDs). The $157,568 award, effective from November 13, 2024 to June 30, 2026, will support research at Drexel University to: Use circuit-specific optogenetic stimulation to rescue HIV-induced deficits in extinction...
The National Institute on Drug Abuse (NIDA) awarded a 3-year, $1,127,388 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Florida to study the role of the neuronal protein Rac1 in cocaine-seeking behavior. The research aims to determine how Rac1 signaling within neuronal ensembles that control cocaine-seeking impacts the behavioral, structural, and activity patterns of these neurons. The overarching goal is to provide new insights into the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,785,632.00 in funding to the University of Pittsburgh to conduct research on the role of astrocytic dopamine signaling in the nucleus accumbens and its impact on cue-conditioned motivated behaviors and cocaine relapse. The research aims to elucidate the synaptic function of astrocytic dopamine D1 receptors and their involvement in a...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $2,015,823 to Drexel University to conduct research on regulating dopamine transport through allosteric modulation. The key objectives are to: Elucidate the mechanisms of allosteric transporter modulation of the dopamine transporter (DAT) through computational modeling, molecular simulations, and functional/biochemical studies. Evaluate the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,996,709.00 to the Trustees of Indiana University (Indianapolis) to investigate the role of cortical excitatory projections in cocaine addiction. The project aims to examine the excitability of cortical pyramidal neurons in the supplementary motor cortex and the excitatory transmission in the projection to the dorsolateral striatum,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the interplay between cocaine-induced synaptic proteomic adaptations and the underlying transcriptional responses within the nucleus accumbens of the brain's reward system. The $180,606 award, with a performance period from April 1, 2025 to March 31, 2030, will be used by the Icahn School of Medicine at Mount Sinai to elucidate the...
This federal Project Grant award of $189,644 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to characterize the function of several transcript variants of the dopamine D3 receptor (DRD3) gene and their role in regulating cocaine-seeking and taking behavior in rats. The research will be conducted by Wake Forest University Health Sciences, a leading academic medical center. The project aims to: 1) functionally...
This $492,000 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports a multidimensional investigation into the genetic and epigenetic factors underlying cocaine addiction. The University of Chicago, the awardee, will conduct high-resolution chromatin accessibility and DNA methylation profiling to delineate cell-type and circuit-specific epigenetic configurations following cocaine self-administration in...