This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,996,709.00 to the Trustees of Indiana University (Indiana University Indianapolis) to investigate the role of cortical excitatory projections in cocaine addiction. The 5-year project, which runs from September 30, 2024 to May 31, 2029, aims to examine the excitability of cortical pyramidal neurons in the supplementary motor cortex and the excitatory transmission in the projection from this region to the dorsolateral striatum. The goal is to gain a better understanding of the brain adaptations that contribute to persistent drug-seeking behaviors, and to identify potential novel targets for clinical management of drug relapse. This research project builds on extensive prior studies focused on the medial prefrontal cortex and nucleus accumbens in relation to cocaine addiction.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $652.7k | 5/15/25 | ||
| Not listed | $672.0k | 9/16/24 | ||
| Not listed | $672.0k | 9/16/24 |