Project Grant K01DA060334
Award Date
4/1/25
Completion Date
3/31/30
Dollars Obligated
$181K
Federal Agency
National Institute on Drug Abuse
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $180,646 to investigate the molecular mechanisms by which astrocytes, a type of brain cell, regulate cocaine addiction-related behaviors. The primary awardee, the Icahn School of Medicine at Mount Sinai, will conduct the research under the mentorship of Drs. Eric Nestler, Paul Kenny, and Li Shen. The project aims to elucidate the...
This $492,000 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports cutting-edge research to elucidate the genetic and epigenetic factors governing cocaine addiction. The University of Chicago, the prime awardee, will employ a multidimensional approach involving genomics, epigenomics, neuroscience, and computational biology. The key objectives include: 1) Profiling cell-type and circuit-specific...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $295,325 to support the development of a novel epigenetic regulator as a treatment for cocaine use disorder. The project, conducted by Epivario Inc., a for-profit biotechnology company, aims to establish a new lead compound, EPV, as a viable ACSS2 inhibitor with improved pharmacological properties compared to the previously tested ADG-205...
The National Institute on Drug Abuse (NIDA) awarded Vanderbilt University a $149,284 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 26, 2024. The grant aims to define how chronic cocaine use disrupts the brain's dopaminergic system and its ability to process aversive stimuli. Specifically, the project will use single-cell calcium imaging and optogenetic manipulation in behaving animals to establish the temporal conditions under which dopamine...
This $358,012 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to determine the specific excitatory and inhibitory neural circuit mechanisms in the nucleus accumbens that are modulated by inhibition of the angiotensin-converting enzyme (ACE). The research aims to elucidate how ACE inhibition alters synaptic plasticity in medium spiny neurons that express dopamine-1 or -2 receptors, which...
This $505,993 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under CFDA 93.279 - Drug Use and Addiction Research Programs supports research at the University of California, San Diego (UCSD) to investigate the differential roles of prefrontal cortical interneurons in drug-seeking behavior after withdrawal from cocaine use.
The key objectives are to: 1) directly monitor the activity of different types of interneurons in the infralimbic cortex during cocaine...
This $251,250 federal Project Grant award from the National Institutes of Health under the Drug Use and Addiction Research Programs (CFDA 93.279) will support a study by the University of Massachusetts Medical School to explore the role of the neuropeptide nociceptin (NOF/Q) in suppressing cocaine reward in the nucleus accumbens brain region. The exploratory study aims to characterize NOF/Q's effects on cocaine reward and the underlying neural circuitry, leveraging cutting-edge viral and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), provides $158,024 to the University of California, Irvine to investigate the role of the gene GILZ in regulating cocaine-induced cellular activity and cocaine-associated memory formation. The research aims to determine if GILZ, an X-linked gene, mediates sex-dependent transcriptional changes underlying reward-associated behaviors in response to...
This $284,040 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to map molecular changes associated with chronic opioid exposure in specific cell populations and projections within the habenula (HB) brain region. The Lieber Institute for Brain Development, a non-profit medical research institute, will lead this 2-year project using integrated single-cell and spatial transcriptomic...
This federal Project Grant award, provided by the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to examine the molecular and cellular changes in the habenula-interpeduncular circuit during opioid tolerance and withdrawal.
The $601,612 grant, awarded on September 15, 2024, will allow researchers at the Icahn School of Medicine at Mount Sinai to use viral approaches, ribosome profiling, and calcium imaging techniques to...