This federal Project Grant award of $180,646 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the molecular mechanisms underlying the regulation of cocaine drug-seeking behavior by astrocytic CREB. The principal investigator will build an independent research program to elucidate the transcriptional and epigenetic regulation of astrocytes in the context of drug abuse and addiction. Key...
This $454,500 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant funds a research project titled "HIV Effects on Astrocytic Regulation of Stress-Induced Cocaine Reinstatement" at Drexel University. The overarching goal is to investigate the interaction between HIV infection, cocaine use, and stress responses, with a focus on understanding how astrocyte cells mediate these...
The National Institute on Drug Abuse (NIDA), an agency within the U.S. Department of Health and Human Services, awarded a $1,447,919 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Pennsylvania State University to conduct research on cocaine addiction and the "need-state hypothesis." The key objectives are to: Test whether treatment with a GLP-1 receptor agonist can block the aversive behavioral and physiological responses to a cocaine-predictive cue...
This National Institute on Drug Abuse (NIDA) Project Grant award under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the comorbidity of HIV and cocaine use disorders (CUDs). The $157,568 award, effective from November 13, 2024 to June 30, 2026, will be used by Drexel University to conduct a series of studies in male and female mice. The researchers will employ circuit-specific optogenetics to stimulate...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the role of the reelin protein in the cellular and behavioral response to drugs of abuse. The total funding amount is $215,613.00 over the project period from September 13, 2024 to March 31, 2027. The principal investigator at the University of Alabama at Birmingham will use a multidisciplinary approach to examine how reelin...
The National Institute on Drug Abuse (NIDA) awarded a $249,236 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to Duke University to study the role of chromatin regulation and brain-derived neurotrophic factor (BDNF) in cocaine craving and addiction. The research aims to define the changes in chromatin architecture and gene expression in dopamine neurons of the ventral tegmental area that occur after forced abstinence from chronic cocaine use, and to test the requirement...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) totals $201,250 and runs from August 1, 2024 to July 31, 2026. The award supports research by The Research Foundation for the State University of New York (RF SUNY) to investigate the role of astrocyte mitochondria bioenergetics in heroin-induced neuroplasticity. Specifically, the project aims to: 1) Identify the contribution of astrocyte mitochondria...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $121,323 to the University of North Carolina at Chapel Hill to investigate the structural and functional responses of nucleus accumbens microglia following long-access cocaine self-administration in male and female rats. The research aims to: 1) explore morphological responses of accumbens microglia and evidence of astrocyte membrane...
The National Institute on Drug Abuse (NIDA) awarded a $1,039,420 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Medical University of South Carolina (MUSC). The 5-year grant, running from June 1, 2025 to February 28, 2030, will support research aimed at characterizing the transcriptomic profiles and causal functions of specific neuronal ensembles within key brain circuits that govern the facilitation and disinhibition of alcohol and opioid seeking...
This $1,127,388 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to determine the role of the small molecule Rac1 in neuronal ensembles governing cocaine-seeking behavior. The University of Florida is the primary awardee, with the overall objective to examine how Rac1 signaling impacts the behavioral, structural, and activity characteristics of neurons associated with cocaine-seeking. The...