This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
The National Institute on Drug Abuse (NIDA) awarded a $1,465,275 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Alabama at Birmingham (UAB). The grant, with a project period from May 1, 2025 to March 31, 2030, will support research on the role of HIV proteins in psychostimulant abuse. The research aims to investigate how HIV proteins, such as the trans-activator of transcription (Tat) protein, can alter the molecular actions and behavioral...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $240,108 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the dysregulation of reward-seeking behavior in the comorbid condition of HIV and cocaine use disorder (CUD). The research aims to use circuit-specific optogenetics and chemogenetics in mouse models to understand how HIV infection,...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470.00 in funding to Drexel University to develop a new imaging pipeline and analytical approach for examining the spatial architecture of histone dopaminylation in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to connect molecular-level epigenetic changes with behavioral outcomes...
This Project Grant award, valued at $629,844.00, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will support research at Duke University to elucidate the function of the ventral tegmental area (VTA) circuits and their contribution to the learning and performance of motivated behaviors. The research will use bidirectional optogenetics, in vivo electrophysiology and photometry, and quantitative behavioral...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is focused on validating a novel computational neurobiological model of costly drug-taking behavior centered on the striosomes of the dorsomedial striatum. The $1,766,868 award to the University of Texas at El Paso will use electrophysiology, optogenetics, and advanced modeling techniques to investigate the role of the prelimbic-striosomal and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $552,629 to Temple University to conduct research on the use of chemokine receptor antagonists (CRAs) for treating methamphetamine use disorder (MUD). The research aims to characterize the efficacy of three CRAs (AMD3100, Maraviroc, and R-103) in preclinical models of MUD, evaluating their ability to reduce methamphetamine intake, reinforcing...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $445,500.00 to the University of Alabama at Birmingham (UAB) to conduct high-throughput identification and characterization of conserved regulators of drug-induced plasticity in the Caenorhabditis elegans nervous system. The goal is to generate comprehensive molecular, behavioral, and neuronal activity atlases in response to acute and...
The National Institute on Drug Abuse (NIDA) awarded a $1,076,018 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Dynamicare Health Inc. in Wareham, MA. The award will fund a Phase II randomized clinical trial to evaluate the efficacy of DCH-003, a digital therapeutic that delivers contingency management for the treatment of stimulant use disorder. The trial will compare standard clinic care plus DCH-003 to standard care plus a sham digital app, with the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $587,162 to Virginia Commonwealth University to investigate the role of norepinephrine transporter (NET) phosphorylation in amphetamine-induced reward behaviors. The research aims to fill critical gaps in understanding how post-translational modifications to NET, a key mediator of noradrenergic neurotransmission, contribute to the complex...