Project Grant R03AG095539
- This $428,397 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year research study on the anatomical and functional characteristics of the thymus in the elderly human population. The research team at the University of Pikeville will conduct qualitative and quantitative assessments of thymic structure and function in cadaver samples, using techniques such as immunohistochemistry and molecular biology to determine the degree of thymic...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This federal Project Grant award of $3,445,585 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms and genetic factors underlying human ovarian aging. The research aims to advance scientific understanding of how ovarian aging proceeds and its connections to broader women's health outcomes. The award recipient, The Trustees of Columbia University in the City of New York, will utilize single-cell sequencing techniques to...
- This federal Project Grant award in the amount of $124,875.00 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to Cedars-Sinai Medical Center. The grant supports research by Dr. Larissa Langhi Prata, an Assistant Professor at the Kogod Center on Aging at Mayo Clinic, to investigate the role of senescent cells in the susceptibility of elderly and chronically ill patients to infectious diseases. The research aims to provide insights into the biology of aging and its...
- This Project Grant award of $576,723.00 was provided by the National Institute on Aging (NIA), a component of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The award supports research to investigate the role of senescent cancer-associated fibroblasts (SenCAFs) in the progression of breast cancer, particularly in older individuals. Key objectives include determining the organ-specific effects of SenCAFs on metastatic breast...
- This $846,358 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to build a research platform to assess the senescence-associated secretory phenotype (SASP) in vivo. The goal is to elucidate the molecular identity of the SASP secretome and develop biomarkers to distinguish senescence and SASP signatures across different tissues. To accomplish this, the award will leverage a novel SASP-ER platform that permits conditional tagging of secreted proteins in...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research in New York aims to understand the cellular mechanisms that regulate lymph node maintenance and atrophy during aging. The $513,957 award will support research to investigate the role of lymphatic endothelial cell NF-κB signaling in adult lymph node homeostasis. Key objectives include determining the effects of aging on lymph node lymphatic...
- This $463,625 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to better understand the effects of aging on the lung adenocarcinoma (LUAD) tumor microenvironment. The Icahn School of Medicine at Mount Sinai will use single-cell RNA sequencing and spatial analysis technologies to characterize age-related cellular and molecular changes in the LUAD tumor microenvironment. This research aims to uncover new therapeutic opportunities to modulate...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Florida provides $383,750.00 to investigate the role of age-associated immune modulation and cellular senescence in the progression of papillary thyroid carcinoma in older adult patients. The key objectives are to: (1) identify the contribution of advanced age to the senescence-associated secretory phenotype (SASP) in thyroid tissue, and (2) characterize alterations in the SASP transcriptome of aged thyroid fibroblasts due to local and locoregionally advanced papillary thyroid cancer. This innovative research aims to better understand the interplay of age and SASP production in thyroid tissue in order to guide personalized management of older adult patients with papillary thyroid carcinoma. The award period is from August 15, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $383.8k | 8/12/25 |