Project Grant R21AG098189
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Kentucky Research Foundation a $595,769 Project Grant effective September 15, 2025, through August 31, 2030, under the Aging Research program (CFDA 93.866). The research investigates the role of RNA modifications, specifically adenosine-to-inosine (A>I) conversions, on the translation of circular RNAs (circRNAs) in Alzheimer's disease (AD) progression. The study focuses on circRNAs derived from...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- Federal Grant Award Summary The National Institute on Aging awarded a $666,504 Project Grant to the University of Kentucky Research Foundation on February 1, 2026, under the Aging Research program (CFDA 93.866). This five-year research initiative, extending through January 31, 2031, focuses on developing and validating noninvasive magnetic resonance imaging (MRI) biomarkers to assess muscle quality in older adults with knee osteoarthritis. The project will evaluate advanced MRI techniques,...
- Summary The University of Arkansas, Fayetteville is conducting fundamental biomedical research on skeletal muscle aging and rejuvenation under a $141,890 Project Grant (R01) awarded by the National Institute on Aging through its Aging Research program (CFDA 93.866). The project, spanning from June 1, 2025 through July 31, 2030, investigates the role of the MYC transcription factor in mediating muscle functional, metabolic, cellular, and molecular plasticity across the lifespan. Researchers...
- Federal Project Grant Award Summary The National Institute on Aging awarded $698,690 to the University of Wisconsin-Madison under its Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This Project Grant supports basic research investigating the molecular mechanisms underlying fiber type-specific skeletal muscle dysfunction in aging populations. The research project will deliver scientific findings and data products examining how aging affects slow...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $852,273 through the Aging Research program (CFDA 93.866) to conduct a comprehensive genetic mapping study of RNA modifications in the aging human brain and their association with Alzheimer's disease (AD). This project grant, initiated September 1, 2025, with completion targeted for May 31, 2030, will deliver a multi-faceted research effort examining how genetic...
- The University of Kentucky Research Foundation was awarded $382,830 on February 15, 2026, under the National Institute on Aging's Aging Research program (CFDA 93.866) to conduct longitudinal research examining recovery trajectories following critical illness in older adults. This five-year project, concluding January 31, 2031, is designed to identify clinical and cellular factors that contribute to disparate physical function and activities of daily living (ADL) recovery outcomes in intensive...
- Federal Project Grant Summary The National Institute on Aging awarded a Project Grant totaling $567,224 to the University of Rhode Island (effective February 1, 2026, through January 31, 2031) under the Aging Research program (CFDA 93.866) to investigate tissue-specific modulation of mitochondrial deoxyribonucleic acid (mtDNA) mutations and their relationship to aging and age-related diseases. The research will examine how different tissues accumulate and clear mtDNA mutations using genetic...
- Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective January 15, 2026, with completion targeted for December 31, 2027. The award supports development of innovative magnetic resonance imaging (MRI) analysis tools and frameworks designed to identify microstructural and structural biomarkers of skeletal muscle health across the lifespan. The research...
The National Institute on Aging (NIA) awarded $616,000 in Project Grant funding to The University of Kentucky Research Foundation on February 1, 2026, under the Aging Research program (CFDA 93.866) for a three-year project period concluding January 31, 2029. This grant supports the development of innovative computational and experimental approaches to map and understand RNA modifications in aging muscle tissue. The primary deliverables include the creation of novel detection methods for RNA modifications, particularly 5-methylcytosine (M5C), utilizing nanopore sequencing technology and artificial intelligence. Additionally, the project will produce synthetic RNA training strategies to improve modification detection accuracy and establish comprehensive analyses of how modification patterns differ across muscle fiber types by age and sex. The research will integrate chemical biology, machine learning, and muscle physiology to examine the impact of RNA modifications on protein synthesis and identify potential RNA-based therapeutic targets for age-related muscle loss. Beyond the specific research outputs, the project is designed to establish new paradigms for studying RNA modifications in aging tissues and provide valuable resources and methodologies for the broader aging research community, advancing fundamental understanding of muscle aging mechanisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $616.0k | 1/21/26 |