Project Grant K01AG090746
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is supporting the development of a "Multimodal, Multiscale and Multistage Systems Biology (M3SB) Infrastructure for Precision Medicine in Alzheimer's Disease and Longevity". The $802,034 award aims to conduct multi-modal analyses of genetics, multi-omics data, cross-species protein interactome networks, and human brain-specific functional genomic data to identify...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to compare state-of-the-art biological age clocks across epigenetic, proteomic, and neuroimaging modalities. The goal is to identify complementary signatures of biological aging, disease progression, and resilience in sporadic late onset Alzheimer's disease (SLOAD) and autosomal dominant Alzheimer's disease (ADAD). The $128,373 award, effective August 15, 2025 through May 31, 2030, will...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $167,940 project grant to The Children's Hospital Corporation (Boston Children's Hospital) to elucidate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease. The project, awarded on August 15, 2025, aims to (1) determine if the MEF2 transcription factors mediate survival of specific neuronal subtypes vulnerable to Alzheimer's pathology, (2) assess whether...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- The Project Grant titled "The Role of Neighborhood Social Exposome Dynamics in Risk and Resilience to Alzheimer's Disease and Related Dementias" was awarded by the National Institute on Aging (NIA), under CFDA Program 93.866 - Aging Research. The $3,039,714 grant, with a performance period from September 15, 2025 to September 14, 2029, will investigate the pathways between 30 years of neighborhood-level social exposome change, individual modifiable Alzheimer's disease and related...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- This federal Project Grant award for $366,648.00 was provided by the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), to New York University (NYU). The funding supports the development of statistical methods for improving estimation and prediction models related to Alzheimer's disease (AD) progression, leveraging data from longitudinal cohort studies. Specifically, the project aims to address challenges posed by complex truncation and censoring...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $320,511 project grant to TRU Diagnostics Inc. to develop a novel diagnostic tool for chronic diseases. The project aims to create a "non-stochastic W function epigenomic roadmap" using systems-based dynamic modeling to capture the shifting homeostatic set points of epigenetic markers over time. This transformative approach aims to enable personalized, dynamic health forecasts...
- The National Institute on Aging awarded a Project Grant of $455,274 to The Johns Hopkins University on May 15, 2025 under the Aging Research Federal Grant Program (CFDA 93.866). The objective of this project is to develop and apply statistical methods to improve scientific inferences in Alzheimer's disease (AD) research when using cross-sectional or longitudinal study designs. The proposed approaches aim to handle age-specific prevalent cases in case-control studies, develop regression methods...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $126,640.00 in funding to the University of Florida to conduct research aimed at identifying a robust measure of allostatic load (AL) and key risk/protective factors influencing changes in AL across the adult lifespan. The primary objectives are to: 1) develop a DNA methylation surrogate of AL that can predict health outcomes in two large population datasets; 2) examine AL change patterns across different life stages; and 3) use advanced machine learning techniques to identify critical risk and protective factors for AL changes. The findings will establish guidelines for AL measurement, highlight intervention periods, and inform the design of tailored programs to support healthy aging. The award has an ultimate completion date of May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $126.6k | 8/28/25 |