This Project Grant award of $2,220,017.04 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of the molecular and cellular networks in the mood regulation circuitry of major depressive disorder (MDD). The overarching objective is to generate single-cell transcriptomic profiles to study molecular changes, including those specific to genetic ancestry and sex, associated with MDD...
This Project Grant award of $535,153 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of molecular and cellular networks involved in mood regulation in major depressive disorder (MDD). The project aims to identify transcriptomic changes associated with MDD in a sample of 800 subjects across three key brain regions: the anterior cingulate cortex, basolateral amygdala, and...
This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate the neurobiological, genetic, and environmental factors that influence vulnerability or resilience to depression in children at high familial risk. The $249,000 award, spanning September 2024 to August 2027, will enable the awardee, The Trustees of Columbia University in the City of New York, to conduct a multi-generational study...
The National Institute of Mental Health (NIMH) awarded a $252,125 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Trustees of Columbia University in the City of New York to conduct research on the neural mechanisms underlying context-dependent decision-making. The research aims to use functional magnetic resonance imaging (fMRI) in mice to identify brain regions involved in maintaining contextual information to guide decisions, and then employ optogenetics...
This $246,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at The University of Texas Southwestern Medical Center (UT Southwestern) to investigate age-dependent dysfunction in the dentate gyrus (DG) region of the hippocampus and its relationship to the pathophysiology of psychosis. The research aims to reverse-translate discoveries from post-mortem human brain analyses, specifically...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $811,404 to The Trustees of Columbia University in the City of New York to conduct research on the neural circuitry underlying anticipatory anhedonia in schizophrenia. The research aims to utilize a computational psychiatry approach to dissect the neural mechanisms of altered reward anticipation, which may serve as novel targets for treating...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $184,476 to the University of Southern California to conduct a large-scale mapping of brain morphometry in Bipolar Disorder (BD) and Major Depressive Disorder (MDD). The project builds on 15 years of research by the ENIGMA Consortium's BD working group, applying standardized voxel-wise brain mapping techniques to a sample of 3,500 BD patients,...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $818,253 to The Regents of the University of California, San Francisco (UCSF) for a longitudinal study over 5 years. The study aims to evaluate the association of depression severity, cognition, and motor frailty with abnormalities in the neuromodulatory system, which controls the brain's activity state and behavioral responses. The research will...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $638,872 to The Feinstein Institutes for Medical Research to conduct research on "Elucidating Reward Network Modulation in Medial Forebrain Bundle Deep Brain Stimulation for Treatment Resistant Depression". The goal is to use brain imaging to understand how deep brain stimulation of the medial forebrain bundle impacts the brain's reward processing...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding a $165,980 study to examine neural indices of social and monetary reward processing as predictors of real-world pleasure and affect in adolescents at risk for depression. The study aims to determine whether laboratory-based measures of reward outcome processing predict real-world levels of pleasure and affect, and evaluate whether monetary or...