This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate the neurobiological, genetic, and environmental factors that influence vulnerability or resilience to depression in children at high familial risk. The $249,000 award, spanning September 2024 to August 2027, will enable the awardee, The Trustees of Columbia University in the City of New York, to conduct a multi-generational study examining the relationship between hippocampal structure and function, genetic risk factors, and the onset of depressive symptoms in high-risk children. The research will leverage existing data from rodent models and large human cohorts, such as the Adolescent Brain and Cognitive Development Study, to develop a comprehensive understanding of the biological mechanisms underlying the intergenerational transmission of mood disorders. The findings from this project are expected to inform future R01 applications that will further investigate the emergence of aberrant hippocampal processes and their impact on connected brain regions, as well as the molecular underpinnings of these neurobiological changes.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $249.0k | 8/29/24 |