Project Grant R21MH136525
Award Date
12/16/24
Completion Date
11/30/26
Dollars Obligated
$246K
Federal Agency
National Institute of Mental Health
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Dallas, TX 75390, USA
Similar Awards
This $2,694,945 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) funds research to identify cellular phenotypes related to the etiology, pathophysiology, and symptomatology of schizophrenia. The primary objectives are to: 1) replicate and expand on prior findings linking electrophysiological variables in patient-derived induced pluripotent stem cell (iPSC) models to clinical and cognitive phenotypes of...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants supports research to understand the neurobiological basis of schizophrenia and its impact on hippocampal network dynamics and spatial memory. The $231,547 award to George Mason University, a prominent research university, aims to investigate how NMDA receptor signaling regulates hippocampal oscillations and spatial memory retrieval. The study uses transgenic...
This $735,932 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate the cellular mechanisms underlying positive symptoms in mouse models of schizophrenia (SCZ) genetic risk factors. The award, with a period of performance from April 2025 to January 2030, will be administered by St. Jude Children's Research Hospital. The key focus is to characterize disruptions in thalamocortical (TC) projections...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the neural circuit dysfunction underlying auditory hallucinations in a mouse model of 22q11.2 deletion syndrome, a genetic disorder associated with a high risk of schizophrenia. The $731,035 award, with a funding period from June 1, 2025 to March 31, 2030, will be used by the lead researcher at St. Jude Children's Research...
This $128,000 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research on the neural mechanisms underlying abnormal spontaneous gamma activity in schizophrenia and related mouse models. The project aims to determine if increased spontaneous gamma activity in schizophrenia and mouse models is primarily associated with changes in gamma burst power, rather than other spectral components. The...
This is a $3,498,931 Project Grant awarded on January 15, 2025 by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports the "Cross Scale Interrogation of NPD Genes (SING) in Mice" project, which aims to comprehensively investigate the impact of losing 100 neurodevelopmental and psychiatric disorder (NPD) genes in mice across multiple scales, including gene expression, cellular changes, neural circuits, and...
The National Institute of Mental Health (NIMH) awarded a $1,854,632 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Children's Hospital of Philadelphia (CHOP) to study the relationship between mitochondrial function, synaptic activity, and the development of schizophrenia. The key objectives are to: Investigate mitochondrial biogenesis and turnover in induced pluripotent stem cell-derived neurons from individuals with 22q11.2 deletion syndrome, with and without...
This $3,093,740 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the "A Schizophrenia Extension Study for the NKI Rockland Sample II Project: An Open Resource of Multimodal Brain, Physiology & Behavior from a Community Lifespan Sample." The project will leverage the ongoing NIMH-funded NKI Rockland Sample II (NKI-RSII) study to create an open, multimodal dataset of brain...
This Project Grant award of $535,153 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of molecular and cellular networks involved in mood regulation in major depressive disorder (MDD). The project aims to identify transcriptomic changes associated with MDD in a sample of 800 subjects across three key brain regions: the anterior cingulate cortex, basolateral amygdala, and...
This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...