The U.S. National Institute of Mental Health (NIMH) awarded a $638,872 Project Grant (CFDA 93.242 Mental Health Research Grants) to The Feinstein Institutes for Medical Research, a non-profit research organization, to conduct a study titled "Elucidating Reward Network Modulation in Medial Forebrain Bundle Deep Brain Stimulation for Treatment Resistant Depression." The project aims to use neuroimaging techniques to identify biomarkers of reward network modulation that can predict and guide the use of deep brain stimulation (DBS) to the medial forebrain bundle for treating treatment-resistant depression. The researchers will characterize the temporal changes in reward network functional connectivity induced by DBS and confirm that these imaging changes are reversible and correlate with improvements in reward processing behavior. The goal is to establish objective neuroimaging biomarkers that can be used to optimize DBS programming for this treatment-resistant patient population. The award period is from January 1, 2025 to December 31, 2029.
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