Project Grant R01MH136214

Award Date 12/16/24
Completion Date 11/30/29
Dollars Obligated $811K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
New York, NY 10027, USA
Similar Awards
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,694,945 to the Lieber Institute for Brain Development (LIBD) to conduct research on understanding the cellular and circuit mechanisms underlying schizophrenia. The key products and services to be delivered under this award include: 1) Replicating and expanding on prior findings from 2D cell culture models of patient-derived induced...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the neural substrates of context-dependent decision-making in mice. The $252,125 award, spanning from September 2024 to March 2028, will leverage whole-brain functional magnetic resonance imaging (fMRI) and optogenetic techniques to identify brain regions involved in maintaining contextual information and determine how they...
This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), provides $2,516,931 to conduct translational research on the circuit-level mechanisms underlying auditory hallucinations. The primary research objectives are to elucidate the neurobiological basis of auditory hallucinations through a combination of computational modeling, human neuroimaging, and mouse neurophysiology experiments. Key activities...
This $2,354,604 Project Grant awarded by the National Institute of Mental Health (NIMH, CFDA 93.242 Mental Health Research Grants) aims to better understand the role of the ARC protein complex in cognitive deficits associated with psychotic disorders like schizophrenia. The primary awardee, The General Hospital Corporation (Massachusetts General Hospital), will conduct a multi-pronged research effort to: Derive a quantitative structure-activity relationship to optimize compounds that enhance ARC...
This $197,235 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a four-year research career development program investigating the circuit physiology of cognitive flexibility. The funded research aims to study how acetylcholine signaling in the basal forebrain regulates reward-based reversal learning and behavioral flexibility, which has relevance for mental disorders like schizophrenia, autism...
This Project Grant award of $162,000.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the transcriptional diversity of the human mediodorsal thalamus and its role in the pathogenesis of schizophrenia and bipolar disorder. The key objectives are to: 1) Use single-nucleus RNA-sequencing to define transcriptional signatures of diverse cell types in the human mediodorsal thalamus and explore...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $784,642 to the New York Genome Center, Inc. (NYGC) to leverage electronic health records and genomic data to develop predictive models and subtypes for clinical outcomes in psychosis-related disorders. The key objectives are to: Build machine learning-based models to forecast treatment response, illness severity, medical comorbidities, and...
This federal Project Grant award of $287,000.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Chicago to develop machine learning-based predictive models for clinical outcomes in psychosis-related disorders. The key products and services to be delivered include: Leveraging two large electronic health record (EHR) databases to build individual-level prediction models for four major...
This federal Project Grant award in the amount of $829,966 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports research to investigate the neural mechanisms underlying social information processing, with a focus on understanding how the brain encodes and integrates cues related to social familiarity and hierarchy. The research will utilize advanced neuroimaging techniques, including fiber photometry...
This $182,993 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the role of acetylcholine (ACh) release in the dorsomedial striatum (DMS) and its regulation by thalamostriatal projections during reversal learning. The key objectives are to: 1) determine how optogenetic inhibition of DMS cholinergic interneurons affects the learning rate during a reversal learning task, 2) assess...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $811,404 to The Trustees of Columbia University in the City of New York to conduct research on the neural circuit mechanisms underlying anticipatory anhedonia in schizophrenia.

The key objectives of this 5-year research project are to: 1) Establish the relationship between anticipatory value computation and anhedonia traits through large-scale online experiments; 2) Identify the neural circuitry involved in altered anticipatory value computation using model-based fMRI analysis; and 3) Examine whether the neural alterations responsible for anhedonia could also account for cognitive deficits in schizophrenia. This innovative computational psychiatry approach aims to uncover novel neural circuit alterations that may serve as targets for treating anhedonia and cognitive deficits in schizophrenia.

Generated 6/24/25, 4:55 AM