This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,711,908.00 in funding to the University of California, San Francisco (UCSF) to conduct research on the relationship between depressive symptoms and biomarkers like tau, amyloid-beta, cerebral blood flow, and neurodegeneration in individuals with mild cognitive impairment (MCI). The 5-year study aims to: 1) evaluate the association of depressive symptoms with tau deposition in cortical...
The National Institute of Mental Health (NIMH) awarded a $593,104 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Virginia Commonwealth University (VCU) to conduct research on the risk pathways to major depression. The project aims to advance the etiological understanding of major depression by clarifying the interrelationships between genetic and environmental risk factors over time, leveraging data from the extensive national health registers in Denmark and Sweden. Key...
The National Institute of Mental Health (NIMH) awarded Emory University a $156,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to identify patients who are most likely to fail first-line treatments for major depressive disorder (MDD) and would benefit from earlier referral to alternative therapies. The project will use trajectory classification methods on combined clinical trial and real-world data to distinguish between partial response and true treatment failure...
This federal Project Grant award of $968,769 from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants will fund a study to investigate the efficacy of maintenance repetitive transcranial magnetic stimulation (rTMS) for individuals with treatment-resistant depression. The study will recruit 75 participants across three sites - the University of California San Diego, Cornell University, and Australian National University - into a double-blind, three-arm...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,210,865 to the University of California, Los Angeles (UCLA) to conduct research on identifying unique neural and inflammatory mechanisms of depression in people living with HIV (PLWH). The study will enroll 220 participants, including PLWH who are depressed, PLWH who are not depressed, and HIV-negative individuals who are depressed and not...
This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) provides $919,453 to the Van Andel Research Institute (VAI) to investigate the immunobiological mechanisms underlying depression during the perimenopause period. The project aims to identify specific inflammatory and metabolic markers, as well as epigenetic changes in lymphocytes, that contribute to the increased risk of depression among perimenopausal women. The multi-site...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $898,025 to the University of Cincinnati to evaluate the use of transcutaneous spinal direct current stimulation (tsDCS) to modulate spinal interoceptive pathways (SIPs) and assess their role and therapeutic potential in major depressive disorder (MDD). The award supports a two-phase research study. In the R61 phase, the researchers will use...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $237,000 to the University of California, San Diego (UCSD) to develop translational depression-relevant models in mice. The goal is to better evaluate the efficacy of psychedelic agents, such as psilocybin, in reversing depression-relevant amotivated behaviors and identifying associated electroencephalographic (EEG) biomarkers. Specifically, the...
This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program, aims to improve the understanding and treatment of depression. The $784,096 award to The Leland Stanford Junior University will develop optimized methods for measuring brain excitability in depression using repetitive transcranial magnetic stimulation (rTMS). Specifically, the project will: 1) investigate how adjusting rTMS parameters affects neural...
The National Institute of Mental Health (NIMH) awarded a $729,821 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Alabama at Birmingham (UAB) to conduct research on the role of long non-coding RNAs (lncRNAs) in the pathogenesis of major depressive disorder (MDD). The project aims to mechanistically examine how nuclear lncRNA regulation of 3D chromatin organization and epigenomic reprogramming in a cell type-specific manner may contribute to transcriptional...