This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,119,505.00 to Temple University to conduct research on the role of mitochondria in the pathogenesis of eosinophilic esophagitis (EoE). The research aims to elucidate the direct molecular mechanisms through which the cytokine IL-13 regulates mitochondrial biology in esophageal...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,485,507 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the role of CD73 in esophageal epithelial homeostasis. The 4-year project aims to: 1) define the requirement of squamous epithelial CD73 in esophageal homeostasis and response to eosinophilic esophagitis...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the mechanisms by which the aryl hydrocarbon receptor (AhR) mediates both protective and detrimental effects on eosinophilic esophagitis (EoE), an allergic disease of the esophagus. The $1,246,628 award, effective from August 15, 2024 through June 30, 2029, will support the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $568,296 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Colorado-Denver. The grant, titled "Innovations in Treatment Adherence in Pediatric Eosinophilic Esophagitis", aims to develop and pilot test a "Medication Habit Action Plan" to improve medication adherence in adolescents with eosinophilic esophagitis, a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $226,980.00 to Thomas Jefferson University over a 2-year period starting February 1, 2025. The funding supports research to determine the role of the GPR15-C10ORF99 pathway in T cell homing to the esophagus and the pathogenesis of eosinophilic esophagitis (EoE). The research aims to investigate if this molecular pathway is required for T cell...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $1,222,594 to Vanderbilt University Medical Center to investigate the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment associated with eosinophilic esophagitis. The research aims to determine...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,375,359.00 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the molecular mechanisms underlying epithelial barrier dysfunction in eosinophilic esophagitis (EOE). The key objectives are to: 1) Examine the roles of STAT1 and STAT3 transcription factors in regulating STAT6-mediated epithelial...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding the mechanisms by which microbially derived metabolites regulate host gut inflammation. The award period runs from August 28, 2024 to February 28, 2027. The research aims to determine the regulatory...
This $548,802 Project Grant, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) on September 19, 2024, aims to improve the colonization and engraftment of the live biotherapeutic product Escherichia coli Nissle 1917 (ECN) in the presence of phage predation. The funding will support research by Ancilia Biosciences Inc. to engineer a CRISPR-Cas system that can provide phage immunity to ECN,...
This $1,543,110 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to New York University School of Medicine aims to better understand how the gut microbiome and other host factors determine urine oxalate levels. The research has three key objectives: Investigate the role of the "oxalobiome" (microbes that degrade oxalate) in determining urine oxalate excretion, and whether it differs between kidney stone formers and non-stone...