Project Grant R01DK136987

Award Date 8/15/24
Completion Date 5/31/28
Dollars Obligated $2.1M
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19140, USA
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This $183,600 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the University of Utah to investigate the impact of dietary changes on the gut microbiome and its relationship to eosinophilic esophagitis (EoE). The 5-year research project aims to: 1) characterize the fecal microbial composition, gene expression, and metabolites associated with...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $1,222,594 to Vanderbilt University Medical Center to investigate the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment associated with eosinophilic esophagitis. The research aims to determine...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,485,507 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the role of CD73 in esophageal epithelial homeostasis. The 4-year project aims to: 1) define the requirement of squamous epithelial CD73 in esophageal homeostasis and response to eosinophilic esophagitis...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the mechanisms by which the aryl hydrocarbon receptor (AhR) mediates both protective and detrimental effects on eosinophilic esophagitis (EoE), an allergic disease of the esophagus. The $1,246,628 award, effective from August 15, 2024 through June 30, 2029, will support the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $226,980.00 to Thomas Jefferson University over a 2-year period starting February 1, 2025. The funding supports research to determine the role of the GPR15-C10ORF99 pathway in T cell homing to the esophagus and the pathogenesis of eosinophilic esophagitis (EoE). The research aims to investigate if this molecular pathway is required for T cell...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $594,956 to the University of South Florida to conduct research on the mechanisms underlying stretch-evoked activation of esophageal vagal afferents. The goal is to determine the mechanosensitive channels and sodium channels responsible for transducing esophageal stretch into vagal afferent...
This $464,985 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the regulation and consequences of extracellular vesicles (EVs) released from adipocytes (fat cells) in obesity-related cardiometabolic disease. The research, conducted by Washington University, aims to 1) determine how the production and release of adipocyte...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $568,296 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Colorado-Denver. The grant, titled "Innovations in Treatment Adherence in Pediatric Eosinophilic Esophagitis", aims to develop and pilot test a "Medication Habit Action Plan" to improve medication adherence in adolescents with eosinophilic esophagitis, a...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $1,066,994 to Rutgers, The State University to conduct research on the role of the TET3 enzyme in regulating intestinal epithelial cell homeostasis and protection against inflammatory conditions. The research aims to decipher the epigenetic and transcriptional mechanisms by which TET3-mediated DNA oxidation regulates gene expression to maintain intestinal epithelial...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $850,232 to Northwestern University to advance the evolution of the Chicago Classification for diagnosing esophageal motor disorders. The project aims to develop new approaches combining assessments of esophageal neuromyogenic function and geometry to identify biomechanical physiomarkers of...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,119,505.00 to Temple University to conduct research on the role of mitochondria in the pathogenesis of eosinophilic esophagitis (EoE). The research aims to elucidate the direct molecular mechanisms through which the cytokine IL-13 regulates mitochondrial biology in esophageal epithelial cells, and to investigate the functional significance of these mitochondrial alterations with respect to EoE-associated tissue remodeling and inflammation. Additionally, the project will explore the potential of EoE-associated mitochondrial changes to serve as novel biomarkers. The award period runs from August 15, 2024 to May 31, 2028.

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