This $226,980 Project Grant awarded on February 1, 2025 by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Thomas Jefferson University to determine the role of the GPR15-C10ORF99 pathway in T cell homing during eosinophilic esophagitis (EoE).
EoE is a chronic inflammatory disease characterized by eosinophilic infiltration of the esophagus, leading to esophageal dysfunction and fibrosis. This research aims to investigate whether the GPR15-C10ORF99 receptor-ligand pair is required for T cell migration to the esophagus and the development of EoE pathology. The findings could help identify diagnostic markers and therapeutic targets for this condition, which is estimated to cost the U.S. $1 billion annually. The project will leverage the awardee's expertise in the GPR15-C10ORF99 pathway and use molecular genetic tools to study their functions in EoE mouse models.
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