The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $757,364 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Children's Hospital of Philadelphia (CHOP). The grant supports research to define the role of CD73, a critical enzyme involved in esophageal epithelial homeostasis, and how disruption of purinergic signaling contributes to the pathobiology of eosinophilic esophagitis (EOE). Key objectives include determining the direct requirement of CD73 in esophageal homeostasis, elucidating the molecular mechanisms by which adenosine signaling supports epithelial homeostasis, and assessing the relationship between CD73 levels/purine metabolites and clinical features in EOE patients. This research aims to illuminate the functional and mechanistic roles of CD73 and purinergic signaling in esophageal health, and evaluate the therapeutic potential of restoring purinergic signaling in EOE.
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