This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of CD73 in esophageal epithelial homeostasis and its potential therapeutic implications for eosinophilic esophagitis (EoE). The $757,364 award to The Children's Hospital of Philadelphia Research Institute will support a 4-year research project to: 1)...
This federal Project Grant award, valued at $1,222,594.00 and granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment - key features of eosinophilic esophagitis (EoE). The award, with a project period...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,119,505.00 to Temple University to conduct research on the role of mitochondria in the pathogenesis of eosinophilic esophagitis (EoE). The key objectives are to: 1) define the molecular mechanisms through which the cytokine IL-13 regulates mitochondrial biology in esophageal epithelial...
This $594,956 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the mechanisms responsible for transducing esophageal stretch into activation of vagal afferent nerves. The research aims to identify the mechanosensitive receptors, such as Piezo channels, and voltage-gated sodium channels required for action potential...
This $226,980 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program will support research to determine the role of the GPR15-C10ORF99 pathway in T cell homing and the pathogenesis of eosinophilic esophagitis (EoE). EoE is a chronic inflammatory disease of the esophagus with high prevalence and significant clinical and economic impact, but the underlying mechanisms are not well...
This federal Project Grant award of $568,296 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to improve medication adherence in adolescents with eosinophilic esophagitis (EoE), a chronic immune-mediated inflammatory disease of the esophagus. The key objectives are to: 1) establish an optimal "Medication Habit Action Plan" tool through...
This federal Project Grant award in the amount of $1,614,573.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to identify the earliest molecular and genetic changes underlying the transformation from non-dysplastic to dysplastic Barrett's esophagus, a precursor to esophageal adenocarcinoma. The research leverages single-cell...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,882,623.00 to support research on the epigenetic regulation of intestinal tuft cells. The research aims to investigate how distinct components of the intestinal microbiota, through epigenetic mechanisms, calibrate tuft cell responses and regulate tuft cell development and...
This federal Project Grant award of $613,934 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research into the role of the aryl hydrocarbon receptor (AhR) signaling pathway in regulating airway smooth muscle responses during inflammation and asthma. The key objectives are to: 1) Determine the mechanisms of AhR expression and regulation in human airway smooth muscle under inflammatory conditions; 2) Investigate...
This $964,718 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research by Northwestern University to develop and validate a virtual esophagus (VEsophagus) simulation model. The goal is to use this virtual model to predict surgical outcomes for patients with esophageal motility disorders and gastroesophageal reflux disease (GERD)....