This $183,600 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the University of Utah to investigate the impact of dietary changes on the gut microbiome and its relationship to eosinophilic esophagitis (EoE). The 5-year research project aims to: 1) characterize the fecal microbial composition, gene expression, and metabolites associated with...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,485,507 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the role of CD73 in esophageal epithelial homeostasis. The 4-year project aims to: 1) define the requirement of squamous epithelial CD73 in esophageal homeostasis and response to eosinophilic esophagitis...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the mechanisms by which the aryl hydrocarbon receptor (AhR) mediates both protective and detrimental effects on eosinophilic esophagitis (EoE), an allergic disease of the esophagus. The $1,246,628 award, effective from August 15, 2024 through June 30, 2029, will support the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $1,222,594 to Vanderbilt University Medical Center to investigate the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment associated with eosinophilic esophagitis. The research aims to determine...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
This federal Project Grant award of $151,643, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on developing and evaluating Proteolysis Targeting Chimeras (PROTACs) to stabilize hypoxia-inducible factors (HIFs) as a potential therapeutic approach for inflammatory bowel disease (IBD). The principal investigator, Dr. Ornelas Sanchez, and his...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,119,505.00 to Temple University to conduct research on the role of mitochondria in the pathogenesis of eosinophilic esophagitis (EoE). The research aims to elucidate the direct molecular mechanisms through which the cytokine IL-13 regulates mitochondrial biology in esophageal...
This federal Project Grant award of $146,922 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research on the role of gut protist-derived compounds in modulating dietary antigen presenting dendritic cells in celiac disease. The University of Pittsburgh will conduct this research project, which aims to gain insights into how the gut protist Tritrichomonas...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a $389,578 multi-center clinical research project focused on improving the treatment of achalasia, a rare esophageal motility disorder. The project, titled "Precision Medicine in Achalasia - PREMEDIA", aims to test an innovative, tailored approach to per-oral endoscopic...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $163,825 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to study the role of AXL signaling in intestinal fibrosis associated with Crohn's disease. The research aims to unravel the intricacies of the GAS6/AXL signaling pathway and how...