This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $224,424 to The Regents of the University of Colorado (doing business as the University of Colorado-Denver) to investigate the role of inflammasome pathways as molecular mediators of age-related differences in brain injury after global cerebral ischemia induced by cardiac arrest. The research aims to assess for age-related differences in inflammasome-mediated inflammation and evaluate how inflammasome activity contributes to neuronal cell loss, synaptic deficits, and cognitive impairment in young and aged mice after cardiac arrest. This research is expected to elucidate novel aging-relevant mechanisms involved in the brain's response to global cerebral ischemia and provide insights that could lead to new therapeutic strategies for cardiac arrest survivors. The award period runs from August 15, 2024 to July 31, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $224.4k | 8/12/24 |