Project Grant K08AG084902

Award Date 8/15/24
Completion Date 5/31/29
Dollars Obligated $339K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Ann Arbor, MI 48109, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a research project titled "Cell-Type-Specific Dissection of Retrosplenial Circuits in Preclinical Models of Alzheimer's Disease". The $128,321 award, effective December 19, 2024 through June 30, 2026, will be provided to the Regents of the University of Michigan to systematically study changes to retrosplenial cortex circuitry in mouse models of Alzheimer's disease. The research aims to...
This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to investigate the mechanisms underlying neuronal hyperexcitability in the entorhinal cortex (EC) of Alzheimer's disease (AD) mouse models. The $1,758,779 award, effective August 1, 2024 through July 31, 2026, will support studies to determine whether hyperexcitability is due to dysfunction of excitatory or inhibitory neurons in the EC. The research will use...
This Project Grant award of $654,238 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research to identify the role of senescent neurons in brain aging and Alzheimer's disease and related dementias (ADRD). The primary awardee, the University of Texas Health Science Center at San Antonio, will generate spatial omics data from ADRD brains and mouse models, while the co-investigator team at Washington University will provide expertise in experimental design, data...
This $6,226,692 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program supports research examining the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to use a mouse model to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the pathological hallmarks of AD. Key objectives include tracking early...
This Project Grant award of $3,929,011, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is funding a longitudinal, multimodal neuroimaging study to elucidate the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The study aims to identify the earliest manifestations of neural circuit hyperexcitability that predict the accumulation of tau protein and cognitive deficits in individuals...
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This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $303,449.00 to investigate the role of transposable elements (TEs) in Alzheimer's disease (AD) and related dementias (ADRD). The project aims to leverage large genomic datasets to analyze the prevalence and functional impact of TEs on AD and ADRD phenotypes. Key objectives include: Developing a novel cloud-based computational infrastructure to analyze TE patterns in large AD and ADRD cohorts....
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to advance understanding of inhibitory interneuron dysfunction and its contribution to neural circuit dysregulation in Alzheimer's disease (AD) and related dementias. The $338,527 award, effective August 15, 2024 through May 31, 2029, will support the following key activities:

  1. Identifying disrupted interneuron gene expression patterns in post-mortem AD brain samples using spatial transcriptomic analysis to uncover mechanisms driving interneuron pathology and hyperexcitability.

  2. Characterizing dysfunction of AD-derived induced interneurons in vitro, including metabolic profiling and assessments of amyloid-beta toxicity, and genetically modifying these cells to restore regulatory physiology.

  3. Transplanting healthy induced interneurons into an AD mouse model to evaluate the impact on hippocampal-based memory performance and neurodegeneration, providing a foundation for future cell-based therapies.

The research will be conducted by the Regents of the University of Michigan, a prominent public research institution, with the goal of uncovering innovative treatments for AD and other disorders involving disrupted neural networks.

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