The University of Texas Health Science Center at Houston (UTHealth) received a $644,881 Project Grant award from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The funding supports a 5-year research project investigating a novel blood substitution approach to treat acute ischemia in the aged brain, with a focus on preserving mitochondrial function in cerebrovascular endothelial cells and reducing stroke severity. The research aims to demonstrate the potential of this blood substitution therapy as a future treatment for stroke in elderly patients. The project employs in vivo mouse models of focal cerebral ischemia as well as in vitro human and murine cell culture models. UTHealth is the primary awardee but may utilize sub-awards to collaborate with other institutions as part of this comprehensive biomedical research initiative.
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