The National Institute on Aging (NIA) awarded a Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University of Texas Health Science Center at Houston (UTHealth) totaling $644,881 to investigate a novel blood substitution approach for treating acute ischemia in the aged brain. The research aims to demonstrate the potential of blood substitution therapy to reduce stroke severity by removing neutrophils and matrix metalloproteinase-9 (MMP-9) from the blood,...
This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $663,000 to the University of Texas Health Science Center at Houston to conduct research on the role of cellular senescence in driving sex-specific outcomes of small vessel disease and post-stroke cognitive impairment. The research aims to understand the chronic neurological consequences of small vessel disease following stroke, and evaluate whether delayed treatment strategies targeting the...
The National Institute on Aging awarded $3,391,684 under the Aging Research grant program (CFDA 93.866) to Texas A&M University Health Science Center from May 1, 2022 to April 30, 2025. The project aims to test the hypothesis that peripheral insulin-like growth factor-1 (IGF-1), delivered intraperitoneally or orally, will improve acute stroke disability as well as chronic depressive-like behaviors and cognitive impairment post-stroke in a rodent model. Researchers also expect peripheral...
The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,387,438 under the Aging Research program (CFDA 93.866) to The Ohio State University Office of Sponsored Programs on September 19, 2022. The three-year project grant aims to develop and test a novel neuroprotective agent, TAT-M2NX, to provide both acute and sustained synaptic protection following acute ischemic stroke. The research seeks to characterize the agent's...
This $454,225 Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) will support research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop new methods for assessing "effective reserve" in patients with acute ischemic stroke. The key objectives are to: 1) investigate the concept of effective reserve and its feasibility in acute ischemic stroke patients using two large...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $308,000 will support research to identify and measure non-stroke symptoms associated with carotid artery stenosis in older patients. The project aims to use established NIH assessment tools to evaluate quality of life, cognitive function, and other patient-reported outcomes in patients with carotid artery disease, including those who have undergone prior medical or surgical treatment. The...
The National Institute on Aging (NIA) awarded a $471,885 Project Grant (CFDA 93.866 - Aging Research) to Oregon Health & Science University (OHSU) from June 1, 2025 to May 31, 2027. The project aims to investigate the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury, which can contribute to vascular cognitive impairment and dementia (VCID). Specifically, the project will test hypotheses related to how the glycosaminoglycan hyaluronan and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $431,750 aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice in vivo and senescent versus non-senescent murine VECs in vitro. The primary objectives are to enhance the understanding of molecular mechanisms and age-related pathologies associated with vascular dysfunction during aging. The project seeks to...
This federal Project Grant award of $416,625 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research at Saint Louis University (SLU) to investigate the effects of aging, sex, and hormonal status on atherosclerotic cardiovascular disease (CVD). The key objectives are to: 1) comprehensively map inflammatory cell profiles and cell-cell communication networks in atherosclerotic plaques of young and old male and female mice, including old...