This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $224,424 to The Regents of the University of Colorado (doing business as the University of Colorado-Denver) to investigate the role of inflammasome pathways as molecular mediators of age-related differences in brain injury after global cerebral ischemia induced by cardiac...
This federal Project Grant award for $853,135 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research at Dignity Health's St. Joseph's Hospital and Medical Center in Phoenix, AZ to study the role of the complement C3A receptor in exacerbating brain injury and functional impairment following ischemic stroke. The research aims to...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $424,875 Project Grant under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" to the University of Maryland, Baltimore to conduct research on the role of the TREM2 gene and mitochondrial function in microglia, the immune cells of the brain. The key objectives are to elucidate mitochondrial defects in TREM2-deficient human microglia, determine if the drug idebenone can...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to develop and test a novel biopharmaceutical agent called Sanguinate. The goal is to evaluate Sanguinate's ability to mitigate cerebral infarct growth and improve oxygen delivery in acute ischemic stroke. The $1,223,140 award to the University of Chicago...
This Project Grant award, with a total funding amount of $453,860.00, was issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research aimed at understanding the role of metabolic regulation, particularly AMPK activation, in modulating neutrophil extracellular trap (NET) formation and inflammation following traumatic brain injury...
This $192,500 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to investigate the role of endothelial cell sphingolipid metabolism in acute ischemic stroke outcomes in mice. The primary objectives are to: (1) determine if interventions targeting cerebral endothelial cells can improve stroke outcomes, and (2) evaluate the efficacy of a novel...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 2-year, $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Wayne State University in Detroit, MI. The objective of this high-risk, high-reward research project is to investigate the use of remotely administered hypothermia (RAH) to the spleen as a novel neuroprotective therapy for ischemic stroke. The research aims to determine if suppressing splenic...
This $630,982 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to better understand the mechanisms of neurological injury and the efficacy of neuroprotective strategies used during aortic arch surgery. The study will use noninvasive optical monitoring of cerebral perfusion and oxygenation combined with MRI assessments,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $472,124 to Beth Israel Deaconess Medical Center, Inc. to conduct exploratory studies on the role of TREM1 and TREM2 receptors in the immune response to glioblastoma, an aggressive form of brain cancer. The research aims to use a novel mouse model of glioblastoma to investigate how...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The $245,625 award, which runs from August 7, 2024 to June 30, 2026, will fund the "DELTA ECMO ABI STUDY" to investigate the causes of acute brain injury in patients receiving extracorporeal membrane oxygenation (ECMO) therapy. The research...