Project Grant R21AG085456

Award Date 9/30/24
Completion Date 6/30/26
Dollars Obligated $679K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Fort Collins, CO 80521, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $500,000.00 to Alzarrok Bio LLC to develop a peptide-based multi-target drug for Alzheimer's disease (AD). The goal is to demonstrate the in vivo efficacy of the drug candidate, ALZ100, in inhibiting neuroinflammation and neurodegeneration in an AD mouse model. The project will first determine the therapeutic concentration of ALZ100 in the brain and then evaluate its effects on key...
The National Institute on Aging (NIA) awarded a $295,000 Project Grant (CFDA 93.866 - Aging Research) to Florida International University to develop biotherapeutic nanogels for the treatment of Alzheimer's disease. The goal is to create a novel nanogel system that can effectively cross the blood-brain barrier, inhibit amyloid-beta aggregation, and reduce oxidative stress and neuroinflammation associated with Alzheimer's. The project will focus on improving the nanogel formulation for enhanced...
The National Institute on Aging (NIA) awarded a $1,512,892 Project Grant under the Aging Research program (CFDA 93.866) to 3P Biotechnologies, Inc. to develop a targeted nanoformulation delivery system for the bioactive curcuminoids, curcumin and bisdemethoxycurcumin, to treat Alzheimer's disease (AD). The Phase I project aims to optimize exosome-based formulations of these compounds and assess their biodistribution and toxicity in mice, as well as determine the efficacy of folic...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $3,038,050 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to study the molecular mechanisms of Alzheimer's disease. The funded research aims to discover a novel oxidative stress pathway that targets microglia, the immune cells in the brain, leading to their dysfunction and detrimental consequences in Alzheimer's disease. The goal is to develop...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development of a novel Alzheimer's disease therapeutic using targeted nanoparticles. The $504,732 award to Aphios Corp, a minority-owned biotechnology company, will support two phases of research. In Phase I, the company will nanoencapsulate an anti-CCR5 drug in targeted and non-targeted nanoparticles, characterize the formulations, and evaluate their impact on in vitro models of brain...
The National Institute on Aging (NIA) awarded a $842,175 Project Grant under the Aging Research program (CFDA 93.866) to the J. David Gladstone Institutes in San Francisco, CA. The grant, awarded on December 15, 2024, will fund research to explore the role of the NOX2 enzyme in mediating Alzheimer's disease (AD) pathologies, including network hyperactivity, glucose hypometabolism, and accumulation of amyloid-beta and tau proteins. The research aims to assess the therapeutic efficacy of a novel...
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This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
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This Project Grant award, totaling $679,424, was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to Colorado State University. The project aims to test the efficacy of a novel therapeutic targeting neuroinflammation for protecting against brain aging and Alzheimer's disease-related pathology. Specifically, the research will evaluate the role of the neuroinflammation mediators NF-kB and NLRP3 using a novel class of small molecule "nanoligomers" that can downregulate these targets. The project will conduct a series of preclinical studies in aging wild-type mice and transgenic mouse models of amyloid beta and tau pathology, the main features of Alzheimer's disease. Key objectives include assessing the ability of the nanoligomers to reduce neuroinflammation and protect cognitive function, as well as conducting bioinformatics analyses using human datasets to understand the role of NF-kB/NLRP3-associated neuroinflammation in brain aging versus pathology. The project, which runs from Sep 2024 to Jun 2026, will provide a basis for future larger studies and pilot clinical trials.

Under a sub-award of $67,801, Sachi Bioworks, Inc. will supply the nanoligomer compound SB_NI_112, analyze inflammation markers in brain and tissue samples, and provide guidance on data interpretation and manuscript development to support the overall project goals.

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