This $664,744 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), will fund a randomized Phase I/II pilot clinical trial to evaluate the safety, tolerability, feasibility, and efficacy of phage therapy for reducing recurrent urinary tract infections (rUTIs) in female kidney transplant recipients. The trial will compare phage therapy targeting E. coli and...
This $445,927 Project Grant, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel tool called BACTVUE to enable targeted ablation of infected bladder tissue in patients with antibiotic-refractory urinary tract infections (UTIs). The proposal outlines two primary objectives: 1) Demonstrating BACTVUE's ability to selectively stain diverse...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to explore the feasibility and methodology of performing in vivo genome editing in the urothelium (bladder lining) of live mice. The $207,000 award to New York University School of Medicine will test approaches to deliver CRISPR/Cas9 tools via transurethral...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $117,000.00 to the Research Institute at Nationwide Children's Hospital to conduct research on defining the role of the STAT3 signaling pathway in mediating urothelial defense mechanisms against urinary tract infections (UTIs). The objectives of this 2-year research project are to: 1) Elucidate the mechanisms by...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to provide a mechanistic framework for understanding upper urinary tract (UUT) physiology, with the goal of developing diagnostics and treatments for conditions like vesicoureteral reflux (VUR) and hydronephrosis. The $1,154,840 award to Weill Medical College of Cornell University will fund research using a novel...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $200,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Washington University in St. Louis. The goal of this R56 award is to delineate the molecular mechanism regulating autophagy in Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) caused by UMOD mutations. The university will use CRISPR/Cas9 technology to generate the first...
This $147,486 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research to investigate the impact of type 2 diabetes on the vaginal microbiome and its influence on susceptibility to the bacterial pathogen Group B Streptococcus (GBS). The research aims to define the homeostatic characteristics of the vaginal microenvironment in type 2 diabetes, and characterize how the diabetic vaginal microbiome interacts with GBS and...
This Project Grant award of $360,836 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to improve understanding of the genetic basis of congenital obstructive uropathy (COU) and its subtypes, known as congenital anomalies of the kidney and urinary tract (CAKUT). The research conducted at the Trustees of Columbia University in the City of New York will perform the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,861,715 supports research to develop new treatment strategies for pyelonephritis (kidney infection) by examining the role of intercalated cells in the kidney's innate defense. The research team at Indiana University Indianapolis will investigate the STAT3 signaling pathway in intercalated cells and its...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...