Project Grant R03DK140423

Award Date 6/9/25
Completion Date 4/30/27
Dollars Obligated $117K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Ohio, USA
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This is a Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $632,600 grant will support research to understand the role of antimicrobial peptides called defensins in immunity against urinary tract infections (UTIs) caused by uropathogenic E. coli. The research aims to characterize how defensins synthesized by bladder epithelial cells contribute...
This $1,250,600 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at Indiana University Indianapolis to investigate the role of intercalated cells in the kidney's innate defense against urinary tract infections (UTIs). The research team will examine how intercalated cell phagocytosis and phagosome pH regulation, mediated by the STAT3...
This $577,420 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to provide a mechanistic framework for understanding upper urinary tract (UUT) physiology. The grant supports research conducted by Weill Medical College of Cornell University to define the transcriptional signaling mechanisms and protein complexes required for UUT pacemaker formation and functional...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a randomized Phase I/II pilot clinical trial to evaluate the safety, tolerability, feasibility, and efficacy of phage therapy for recurrent urinary tract infections (UTIs) in female kidney transplant recipients (KTRs). The $664,744 award will support a study comparing phage therapy...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...
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This federal Project Grant award in the amount of $1,592,381.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is for the creation of the Urinary Stone Disease Hub (USDHUB), a comprehensive research resource to support a wide range of clinical investigations on urinary stone disease. The USDHUB will generate a cohort of over 230,000 individuals across the lifespan...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to explore the feasibility and methodology of performing in vivo genome editing in the urothelium (bladder lining) of live mice. The $207,000 award to New York University School of Medicine will test approaches to deliver CRISPR/Cas9 tools via transurethral...
This $625,060 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to elucidate the roles of distinct spinal cord cell types in mediating interstitial cystitis (IC)/bladder pain syndrome (BPS). The research, conducted by The Washington University in St. Louis, will use chemogenetics and optogenetics approaches to determine the...
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This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $117,000 to the Research Institute at Nationwide Children's Hospital to define how the STAT3 signaling pathway in human urothelial cells contributes to antimicrobial defense against urinary tract infections (UTIs). The research aims to: 1) Elucidate the mechanisms by which STAT3 mediates urothelial defense against UTIs in human cell culture, and 2) Identify the transcriptional targets of STAT3 that play key roles in limiting UTI. The anticipated outcome is to enhance understanding of how STAT3 signaling impacts UTI pathogenesis and identify potential therapeutic targets for further investigation. This 2-year project will run from June 2025 to April 2027.

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