This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $577,420 to Weill Medical College of Cornell University to conduct research on defining the onset and regulation of myogenic upper urinary tract physiology. The overall goal is to provide a mechanistic framework of upper urinary tract physiology, which is a critical step in developing...
This Project Grant award for $690,451 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at the University of Pittsburgh to investigate the role of bladder fibroblasts, specifically suburothelial fibroblasts (SUFs), in regulating bladder function and sensation. The research aims to determine the molecular mechanisms by which SUFs...
The federal Project Grant award R01DK139139 for $708,138 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to develop a biomechanocompatible small molecule releasing scaffold for bladder augmentation to address unmet clinical needs in treating patients with end-stage bladder disease. The research project will explore a cell-free approach to drive...
This five-year Project Grant award, valued at $153,540, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by Dr. Katherine Xu at Columbia University's Health Sciences Division to identify genetic risk factors and underlying mechanisms associated with urinary tract infections (UTIs). The research aims to perform genome-wide...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $200,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Washington University in St. Louis. The grant's objective is to delineate the molecular mechanism regulating autophagy in autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by uromodulin (UMOD) mutations. The research aims to develop new therapeutic strategies for ADTKD...
This Project Grant award, valued at $533,907, is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research aims to investigate the role of TET3-mediated DNA oxidation in regulating gene expression in intestinal epithelial cells in response to inflammatory stimuli, such as the gut microbiome and enteric pathogens. The project will employ mouse models with TET3...
This $498,064 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to identify genetic variants that drive the pathogenicity of inflammatory T cells in inflammatory bowel diseases (IBD). The research aims to perform massively parallel reporter assays (MPRAs) on IBD-associated genetic variants in human pathogenic Th17 cells to discover...
This $1,244,042 Project Grant awarded on August 1, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research - supports a center to validate mouse models of prostatic hyperplasia (BPH). The center will bring together three early-stage investigators with complementary expertise in mouse models, inflammation, and bioinformatics to develop new methods for correlating mouse transcriptomic data...
This $521,019 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to evaluate and identify the communication between urothelial cells, sensory neurons, and the brain. The grant supports research at the Medical College of Wisconsin, Inc. to functionally and molecularly characterize the sensory neurons that respond to direct stimulation of...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $243,750 to develop novel methods for detecting mosaic chromosomal alterations (MCA) in non-neoplastic tissues such as the kidney and blood. The goal is to create single-cell sequencing techniques and spatial transcriptomics algorithms that can identify MCA, which are associated with...