Project Grant R21DK140688

Award Date 8/28/24
Completion Date 6/30/26
Dollars Obligated $446K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Richardson, TX 75080, USA
Similar Awards
This $664,744 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), will fund a randomized Phase I/II pilot clinical trial to evaluate the safety, tolerability, feasibility, and efficacy of phage therapy for reducing recurrent urinary tract infections (rUTIs) in female kidney transplant recipients. The trial will compare phage therapy targeting E. coli and...
This federal Project Grant award for $153,540 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at Columbia University to perform human genome-wide association studies (GWAS) to identify genetic risk variants associated with urinary tract infections (UTIs). The research aims to discover novel genes and cell types involved in immune...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,861,715 supports research to develop new treatment strategies for pyelonephritis (kidney infection) by examining the role of intercalated cells in the kidney's innate defense. The research team at Indiana University Indianapolis will investigate the STAT3 signaling pathway in intercalated cells and its...
This $684,107 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, supports research to determine the optimal settings for the Thulium Fiber Laser (TFL) in laser lithotripsy and assess associated thermal injury risk. The key objectives are to: 1) determine the optimal TFL settings through in-vitro studies, 2) elucidate the mechanisms of action of the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $117,000.00 to the Research Institute at Nationwide Children's Hospital to conduct research on defining the role of the STAT3 signaling pathway in mediating urothelial defense mechanisms against urinary tract infections (UTIs). The objectives of this 2-year research project are to: 1) Elucidate the mechanisms by...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $708,138 to support the development of a biomechanocompatible small molecule-releasing scaffold for bladder augmentation. The goal is to create an alternative to conventional surgical approaches that use detubularized bowel tissue, which can have significant complications. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,170 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Latde Diagnostics Corp., a woman-owned small business, to develop a rapid, equitable, lateral flow-based antibiotic susceptibility test (AST) for urinary tract infections (UTIs). The goal of this Phase I project is to demonstrate the feasibility of the Metabolic Amino Acid Phenotyping (MAAP) test kit to provide rapid AST...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $299,608 to The Research Foundation For The State University Of New York (RF SUNY) to investigate the role of Proteus mirabilis RTX proteins in polymicrobial biofilm formation and pathogenesis of catheter-associated urinary tract infections (CAUTI). The research aims to examine how P. mirabilis RTX proteins...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to explore the feasibility and methodology of performing in vivo genome editing in the urothelium (bladder lining) of live mice. The $207,000 award to New York University School of Medicine will test approaches to deliver CRISPR/Cas9 tools via transurethral...

This $445,927 Project Grant, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel tool called BACTVUE to enable targeted ablation of infected bladder tissue in patients with antibiotic-refractory urinary tract infections (UTIs). The proposal outlines two primary objectives: 1) Demonstrating BACTVUE's ability to selectively stain diverse intracellular uropathogenic bacteria, and 2) Leveraging photothermal heating to kill cells harboring BACTVUE-labeled pathogenic bacteria. This research, conducted by the University of Texas at Dallas, has the potential to revolutionize the treatment of recurrent UTIs by specifically targeting and destroying infected bladder tissue, which current therapies struggle to address. The project includes a $12,027 sub-award to the University of Texas Southwestern Medical Center to support patient recruitment and data management for the study.

Generated 8/5/25, 5:02 AM