This National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the mechanisms of cyst inception and growth in autosomal dominant polycystic kidney disease (ADPKD). The $1,472,604 award to the Children's Hospital Medical Center in Cincinnati, OH will be used to develop mouse models that recapitulate the two-hit genetic mutation model of ADPKD...
This $531,999 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research by The Washington University in Missouri to investigate the role of alternative splicing in the progression of diabetic kidney disease (DKD). The key objectives are to: Define and validate the spectrum of alternative splicing events in DKD and in response to...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This $223,918 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the mechanism of kidney resident macrophage (KRM) niche filling as a potential approach to slowing cystic kidney disease progression in autosomal dominant polycystic kidney disease (ADPKD). The research aims to map the kinetics and mechanism of KRM...
This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest stages of podocyte injury in collagen IV nephropathies. The goal is to identify the cellular mechanisms by which mutant collagen IV proteins initiate podocyte damage, leading to chronic kidney disease and end-stage renal failure. The research...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $135,582 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Oklahoma Health Sciences Center to construct a single-cell atlas of mouse and human cells in autosomal dominant polycystic kidney disease (ADPKD). The project aims to understand how molecular and cellular pathways found in ADPKD patients correlate to mouse models, and to identify inter-...
This Project Grant award for $2,029,830 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the structures and stoichiometry of polycystin protein complexes and develop them as biomarkers for autosomal dominant polycystic kidney disease (ADPKD). The research aims to clarify the mechanistic roles of these disease-associated channel proteins,...
This Project Grant award of $214,958 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of Interferon-Stimulated Gene 15 (ISG15) as a regulator of cell death pathways during acute kidney injury (AKI). The research, led by investigators at The Washington University in St. Louis, aims to advance the understanding of the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Emory University a $1,908,038 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to advance the understanding of the role of the apical sodium-dependent bile acid transporter (ASBT) in the pathogenesis of cholestatic liver disease and associated kidney injury. The research aims to elucidate the therapeutic mechanisms of action of systemically acting ASBT...